The Evaluation of Adropin and Autotaxin as Potential Markers of Endothelial Dysfunction in Preeclampsia.

Autor:	Karaca E; Department of Biochemisty, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye., Ercan CC; Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye., Akdemir C; Suleymaniye Gynaecology and Obstetrics, Health Practice and Research Center, Istanbul Health Sciences University, Istanbul, Türkiye., Sivrikoz TS; Department of Gynaecology and Obstetrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye., Salmaslioglu A; Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye., Verit FF; Suleymaniye Gynaecology and Obstetrics, Health Practice and Research Center, Istanbul Health Sciences University, Istanbul, Türkiye., Gurdol F; Department of Biochemisty, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye., Omer B; Department of Biochemisty, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Jazyk:	angličtina
Zdroj:	Angiology [Angiology] 2024 Sep; Vol. 75 (8), pp. 779-785. Date of Electronic Publication: 2023 Aug 17.
DOI:	10.1177/00033197231183228
Abstrakt:	Endothelial dysfunction (ED) plays a prominent role in the pathogenesis of preeclampsia (PE). There is a need for non-invasive methods to assess endothelial function in preeclamptic patients. In the present study, adropin, autotaxin (ATX), and lysophosphatidic acid (LPA) were evaluated as indicators of ED. Patients diagnosed with PE and healthy pregnant women (n = 42 for each group) were compared. After measuring flow-mediated dilation (FMD), the participants were stratified as ED (+) or ED (-) based on a cut-off value of 6.5%. The PE patients were divided as early/late onset PE and severe/mild PE. Adropin, ATX, and LPA levels were measured, and their relevance to ED was evaluated. Student t, Mann-Whitney U, or ANOVA tests were used for statistics, as appropriate. Adropin levels were diminished in the ED (+) group, whereas ATX and LPA levels were increased. The decrease in adropin levels was more pronounced in severe PE, showing a positive correlation with the FMD. In the logistic regression model, adropin was the only parameter that was an independent variable for the FMD test (P < .001). Adropin measurements in serum may be of value for disease follow-up in patients with PE. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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