Coronary artery disease, its associations with ocular, genetic and blood lipid parameters.

Autor: Matulevičiūtė I; Department of Ophthalmology, Lithuanian University of Health Sciences, Kaunas, Lithuania. indre.matuleviciute@lsmu.lt., Tatarūnas V; Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania., Skipskis V; Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania., Čiapienė I; Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania., Veikutienė A; Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania., Lesauskaitė V; Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania., Dobilienė O; Department of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania., Žaliūnienė D; Department of Ophthalmology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Jazyk: angličtina
Zdroj: Eye (London, England) [Eye (Lond)] 2024 Feb; Vol. 38 (2), pp. 372-379. Date of Electronic Publication: 2023 Aug 16.
DOI: 10.1038/s41433-023-02703-9
Abstrakt: Background/objectives: To investigate the associations between ophthalmic parameters, CYP4F2 (rs2108622) and ABCA1 (rs1883025) polymorphisms and coronary artery disease, considering the accessibility, non-invasive origin of retinal examination and its possible resemblance to coronary arteries.
Subjects/methods: Overall 165 participants divided into groups based on the coronary angiography results and clinical status: control group (N = 73), MI group (N = 63), 3VD (three vessel disease) (N = 24). All the participants underwent total ophthalmic examination - optical coherence tomography (OCT) and OCT angiography of the macula region were performed and evaluated. Total cholesterol, high-density lipoprotein, low-density lipoprotein and triglyceride cholesterol (Tg-C) were tested. A standard manufacturer's protocol for CYP4F2 (rs2108622) and ABCA1 (rs1883025) was used for genotyping with TaqMan probes.
Results: GCL+ layer was thicker in control group vs. 3VD group (74.00; 62.67-94.67 (median; min.-max.) vs. 71.06; 51.33-78.44, p = 0.037). T allele carriers under ABCA1 rs1883025 dominant model were shown to have ticker retina and smaller foveal avascular zone in superficial capillary plexus and smaller Tg-C concentration. ABCA1 rs1883025 was associated with retinal thickness (OR = 0.575, 95% CI 0.348-0.948, p = 0.030). Univariate logistic regression showed that ABCA1 rs1883025 CT genotype is associated with decreased risk for coronary artery disease development under overdominant genetic model (OR = 0.498, 95% CI 0.254-0.976; p = 0.042) and codominant genetic model (OR = 0.468, 95% CI 0.232-0.945, p = 0.034).
Conclusions: Results of this study confirmed that non-invasive methods such as OCT of eye might be used for identification of patients at risk of CAD.
(© 2023. The Author(s).)
Databáze: MEDLINE
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