Comparison of the relative impacts of acute consumption of an inulin-enriched diet, milk kefir or a commercial probiotic product on the human gut microbiome and metabolome.

Autor: Walsh LH; Teagasc Food Research Centre, Moorepark, Fermoy, Co, Cork, Ireland.; School of Microbiology Department, University College Cork, Co, Cork, Ireland., Walsh AM; Teagasc Food Research Centre, Moorepark, Fermoy, Co, Cork, Ireland.; School of Microbiology Department, University College Cork, Co, Cork, Ireland.; APC Microbiome Ireland, University College Cork, Co, Cork, Ireland., Garcia-Perez I; Section of Biomolecular Medicine, Division of Computational Systems Medicine, Imperial College London, London, UK., Crispie F; Teagasc Food Research Centre, Moorepark, Fermoy, Co, Cork, Ireland.; APC Microbiome Ireland, University College Cork, Co, Cork, Ireland., Costabile A; School of Life and Health Sciences, University of Roehampton London, London, UK., Ellis R; Surveillance and Laboratory Services Department, APHA, Addlestone, UK., Finlayson J; NHS Highland, Highland Clinical Research Facility, University of the Highlands & Islands, Centre for Health Science, Inverness, UK., Finnegan LA; Teagasc Food Research Centre, Moorepark, Fermoy, Co, Cork, Ireland.; APC Microbiome Ireland, University College Cork, Co, Cork, Ireland., Claesson MJ; School of Microbiology Department, University College Cork, Co, Cork, Ireland.; APC Microbiome Ireland, University College Cork, Co, Cork, Ireland., Holmes E; Section of Biomolecular Medicine, Division of Computational Systems Medicine, Imperial College London, London, UK., Cotter PD; Teagasc Food Research Centre, Moorepark, Fermoy, Co, Cork, Ireland. paul.cotter@teagasc.ie.; School of Microbiology Department, University College Cork, Co, Cork, Ireland. paul.cotter@teagasc.ie.; VistaMilk SFI Research Centre, Teagasc, Moorepark, Fermoy, Co, Cork, Ireland. paul.cotter@teagasc.ie.
Jazyk: angličtina
Zdroj: NPJ science of food [NPJ Sci Food] 2023 Aug 16; Vol. 7 (1), pp. 41. Date of Electronic Publication: 2023 Aug 16.
DOI: 10.1038/s41538-023-00216-z
Abstrakt: It has been established that the human gut microbiota is central to health, and, consequently, there has been a growing desire to positively modulate its composition and/or function through, for example, the use of fermented foods, prebiotics or probiotics. Here, we compare the relative impact of the daily consumption of an inulin-enriched diet (n = 10), a commercial probiotic-containing fermented milk product (FMP) (n = 10), or a traditional kefir FMP (n = 9), over a 28-day period on the gut microbiome and urine metabolome of healthy human adults. None of the treatments resulted in significant changes to clinical parameters or biomarkers tested. However, shotgun metagenomic analysis revealed that kefir consumption resulted in a significant change in taxonomy, in the form of an increased abundance of the sub-dominant FMP-associated species Lactococcus raffinolactis, which further corresponded to shifts in the urine metabolome. Overall, our results indicated that daily consumption of a single portion of kefir alone resulted in detectable changes to the gut microbiota and metabolome of consumers.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
Externí odkaz: