A quick test to objectify smell and taste dysfunction at home: a proof of concept for the validation of the chemosensory perception test.

Autor:	Levesque-Boissonneault C; Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; Department of Speech and Language Pathology, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada., Bussière N; Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; Faculty of medicine, Université de Montreal, Montreal, QC, Canada., Roy-Côté F; Research Center of the Sacré-Cœur hospital, CIUSSS Nord-de-l'Île-de-Montréal, Montréal, QC, Canada., Cloutier F; Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada., Caty MÈ; Department of Speech and Language Pathology, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada., Frasnelli J; Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada.; Research Center of the Sacré-Cœur hospital, CIUSSS Nord-de-l'Île-de-Montréal, Montréal, QC, Canada.; Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Jazyk:	angličtina
Zdroj:	Chemical senses [Chem Senses] 2023 Jan 01; Vol. 48.
DOI:	10.1093/chemse/bjad033
Abstrakt:	Recent studies have shown the efficacy of a home test for the self-evaluation of olfactory and gustatory functions in quarantined coronavirus disease-2019 (COVID-19) patients. However, testing was often limited to COVID-19 participants, and the accuracy of home test kits was rarely compared to standardized testing. This study aims at providing proof of concept for the validation of the new Chemosensory Perception Test (CPT) developed to remotely assess orthonasal olfactory, retronasal olfactory, and gustatory functions in various populations using common North American household items. In the 2 experiments, a total of 121 participants irrespective of having olfactory and/or gustatory complaints from various causes (COVID-19, sinunasal, post-viral, idiopathic) were tested first, with one or many of the following tests: (i) a brief chemosensory questionnaire, (ii) an olfactory test-Sniffin' Sticks Test (SST) or University of Pennsylvania Smell Identification Test (UPSIT), and/or (iii) a gustatory test-Brief Waterless Empirical Taste Test (B-WETT). We then applied the CPT which yielded 3 different subscores, namely orthonasal, retronasal, and gustatory CPT scores. The orthonasal CPT score was significantly correlated with SST (ρ = 0.837, P < 0.001) and UPSIT (ρ = 0.364, P < 0.001) scores, and exhibited an excellent accuracy to identify olfactory dysfunction (OD) as compared to SST (area under the curve [AUC]: 0.923 [95% confidence interval {CI}, 0.822-1.000], P < 0.001). The retronasal CPT score but not the gustatory CPT score allowed to distinguish between participants with or without subjective gustatory complaint (AUC: 0.818 [95% CI, 0.726-0.909], P < 0.001). The CPT has the ability to identify OD and to quantify subjective gustatory complaints. (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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