Diffuse glioma-induced structural reorganization in close association with preexisting syntax-related networks.

Autor: Kinno R; Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan; Division of Neurology, Department of Internal Medicine, Showa University Northern Yokohama Hospital, Yokohama, Japan. Electronic address: kinno@med.showa-u.ac.jp., Muragaki Y; Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan., Maruyama T; Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan., Tamura M; Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan., Ono K; Division of Neurology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan; Department of Neurology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan., Tanaka K; Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan., Sakai KL; Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.
Jazyk: angličtina
Zdroj: Cortex; a journal devoted to the study of the nervous system and behavior [Cortex] 2023 Oct; Vol. 167, pp. 283-302. Date of Electronic Publication: 2023 Jul 24.
DOI: 10.1016/j.cortex.2023.07.005
Abstrakt: Glioma in the left frontal cortex has been reported to cause agrammatic comprehension and induce global functional connectivity alterations within the syntax-related networks. However, it remains unclear to what extent the structural reorganization is affected by preexisting syntax-related networks. We examined 28 patients with a diffuse glioma in the left hemisphere and 23 healthy participants. Syntactic abilities were assessed by a picture-sentence matching task with various sentence types. The lesion responsible for agrammatic comprehension was identified by region-of-interest-based lesion-symptom mapping (RLSM). Cortical structural alterations were examined by surface-based morphometry (SBM), in which the cortical thickness and fractal dimension were measured with three-dimensional magnetic resonance imaging (MRI). Fiber tracking on the human population-averaged diffusion MRI template was performed to examine whether the cortical structural alterations were associated with the syntax-related networks. The RLSM revealed associations between agrammatic comprehension and a glioma in the posterior limb of the left internal capsule. The SBM demonstrated that decreased cortical thickness and/or increased complexity of the right posterior insula were associated not only with agrammatic comprehension of the patients but also with the syntactic abilities of healthy participants. The fiber tracking revealed that the route between these two regions was anatomically integrated into the preexisting syntax-related networks previously identified. These results suggest a potential association between agrammatic comprehension in patients with diffuse glioma and structural variations in specific tracts and cortical regions, which may be closely related to the syntax-related networks.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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