Does resveratrol reduce cisplatin-induced ovarian damage?

Autor:	Ciplak B; Malatya Training and Research Hospital, Clinic of Obstetrics and Gynecology - Malatya, Turkey., Turmus EG; Yeşilyurt Hasan Çalık State Hospital, Clinic of Obstetrics and Gynecology - Malatya, Turkey., Kara O; Ahi Evran University, Faculty of Medicine, Department of Hystology and Embryology - Kırsehir, Turkey., Daglioglu G; Çukurova University, Faculty of Medicine, Department of Biochemistry - Adana, Turkey., Altindag MM; Malatya Training and Research Hospital, Clinic of Obstetrics and Gynecology - Malatya, Turkey., Simsek Y; Biruni University, Faculty of Medicine, Department of Obstetrics and Gynecology - Istanbul, Turkey., Daglioglu YK; Ahi Evran University, Faculty of Medicine, Department of Medical Microbiology - Kırsehir, Turkey., Kara M; Ahi Evran University, Faculty of Medicine, Department of Obstetrics and Gynecology - Kırşehir, Turkey.
Jazyk:	angličtina
Zdroj:	Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2023 Aug 14; Vol. 69 (8), pp. e20230314. Date of Electronic Publication: 2023 Aug 14 (Print Publication: 2023).
DOI:	10.1590/1806-9282.20230314
Abstrakt:	Objective: The objective of this study was to investigate the protectiveness of resveratrol on cisplatin-induced damage to the ovary using experimental models. Methods: A total of 30 female Wistar-Albino rats constituted the research material. The rats were categorized into three groups: Group 1 was administered one milliliter of 0.9% NaCl solution, Group 2 was administered 7.5 mg/kg cisplatin, and Group 3 was administered 7.5 mg/kg cisplatin and 10 mg/kg resveratrol. Ovaries were extirpated in all groups and subjected to biochemical and histopathological tests. Cisplatin-induced damage to ovarian tissue was graded and scored as the total histopathological findings score. The ovarian function was assessed using immunohistochemical staining for c-kit expression. Rats' malondialdehyde, catalase, and superoxide dismutase levels were determined. Results: The histopathological finding score was significantly higher in Group 2 than in other groups (p<0.05). The superoxide dismutase and catalase levels were significantly higher in Group 3 than in Group 2 (p<0.001 for both cases). The malondialdehyde level was significantly higher in Group 2 than in Group 3 (p<0.001). Conclusion: The study findings demonstrated that resveratrol reduced ovarian injury and enhanced biochemical parameters following cisplatin-induced ovary damage in experimental models.
Databáze:	MEDLINE
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