The use of serum alkaline phosphatase as a choledocholithiasis marker to mitigate the cost of magnetic resonance cholangiography.

Autor: Costa PHP; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Sousa JHB; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Lima IT; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Noronha MAN; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Aranha GL; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Arienzo VP; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Lucas PFS; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Steinman M; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Tustumi F; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Einstein (Sao Paulo, Brazil) [Einstein (Sao Paulo)] 2023 Aug 11; Vol. 21, pp. eAO0204. Date of Electronic Publication: 2023 Aug 11 (Print Publication: 2023).
DOI: 10.31744/einstein_journal/2023AO0204
Abstrakt: Objective: To assess the predictive value of preoperative serum laboratory test results for identifying choledocholithiasis and reduce the use of cholangioresonance and its inherent costs.
Methods: Patients aged 21-69 years who underwent preoperative cholangioresonance examination at our institute were included. Patients with a history of fluctuating jaundice or biliary pancreatitis, bile duct dilatation on ultrasonography, and elevated levels of canalicular enzymes (alkaline phosphatase >100U/L and gamma-glutamyl transferase >50U/L) underwent cholangioresonance-guided surgery. Cases of choledocholithiasis confirmed by cholangioresonance were compared with those without choledocholithiasis. Serum laboratory data were evaluated and the diagnostic capabilities of these examinations were analyzed.
Results: A total of 104 patients were included. For detecting choledocholithiasis using alkaline phosphatase, the cut-off point was 78U/L, sensitivity was 97.6% (95%CI: 87.4-99.9), and specificity was 72.6% (95%CI: 59.8-83.1). In the binary logistic regression analysis, age (OR= 0.92; 95%CI: 0.86-0.98) and alkaline phosphatase level (OR= 1.02; 95%CI: 1.01-1.05) were selected for the final model.
Conclusion: Serum alkaline phosphatase levels may aid preoperative diagnosis of asymptomatic choledocholithiasis. After a global clinical assessment of the patient, serum laboratory findings may contribute to a reduction in cholangioresonance-related heathcare costs.
Databáze: MEDLINE
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