| Autor: |
Chelleng N; Natural Product Chemistry Section, CSIR-North East Institute of Science and Technology, Naharlagun, Arunachal Pradesh, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India., Begum T; Natural Product Chemistry Section, CSIR-North East Institute of Science and Technology, Naharlagun, Arunachal Pradesh, India., Dutta PP; Assam down town University, Guwahati, Assam, India., Chetia P; Department of Life Sciences, Dibrugarh University, Dibrugarh, India., Sen S; Assam down town University, Guwahati, Assam, India., Dey BK; Assam down town University, Guwahati, Assam, India., Talukdar NC; Assam down town University, Guwahati, Assam, India., Tamuly C; Natural Product Chemistry Section, CSIR-North East Institute of Science and Technology, Naharlagun, Arunachal Pradesh, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India. |
| Abstrakt: |
Amomum dealbatum Roxb. parts have been traditionally used as remedies for joint pain, diabetes, muscular rheumatism, antiseptic, and abscesses in Arunachal Pradesh, Assam, and Tripura. Ethyl acetate sub-fraction E3 had significantly inhibited the α-glucosidase (IC 50 5.385 μg/mL). The molecular docking revealed quercetin-3-O-galactoside to be the most potent α-glucosidase inhibitor (binding energy -43.214 kcal/mol). Using the QSAR model, the pIC 50 values of myricetin, gallic acid, quercetin-3-O-galactoside, and acarbose were predicted to be 5.65235, 4.39858, 5.65235, and 6.03058, respectively. For the first time, quercetin-3-O-galactoside, myricetin, and gallic acid have been isolated from the flowers of A. dealbatum (ADF). E3 decreased blood glucose level to a near-normal concentration (100.60 ± 2.94 mg/dL) in comparison to diabetic control rats (575.20 ± 24.80 mg/dL). The results have strongly suggested the potential of ADF in treating diabetes. This lesser-known plant has the potential to uncover its full medicinal properties through further in-depth research. |
