A retrospective cohort study of the efficacy of metronidazole in oral lichen planus.

Autor:	Hollis AN; Department of Dermatology, School of Medicine, University of North Carolina at Chapel Hill, NC, USA., Myers EL; Department of Dermatology, School of Medicine, University of North Carolina at Chapel Hill, NC, USA., Culton DA; Department of Dermatology, School of Medicine, University of North Carolina at Chapel Hill, NC, USA.
Jazyk:	angličtina
Zdroj:	Clinical and experimental dermatology [Clin Exp Dermatol] 2023 Nov 16; Vol. 48 (12), pp. 1354-1357.
DOI:	10.1093/ced/llad268
Abstrakt:	Lichen planus (LP) is an inflammatory dermatosis with mucosal variants, including oral LP (OLP). OLP has a relapsing chronic course and may significantly affect a patient's quality of life. We analysed the efficacy of metronidazole as a treatment for OLP via a retrospective chart review of patients with a diagnosis of OLP seen at our institution over 10 years. Thirty patients with OLP were treated with metronidazole 500 mg twice daily. Most patients (n = 18; 60%) showed improvement with metronidazole, including 10 (33%) who experienced complete resolution of symptoms. Our results were limited by the retrospective nature of the review and the relatively small cohort size. Given the efficacy, mild side-effect profile and the less immunosuppressive nature of metronidazole vs. alternative systemic treatment options, metronidazole is a reasonable option to try in patients with symptomatic OLP who have failed topical treatment options. Competing Interests: Conflicts of interest The authors declare no conflicts of interest. (© The Author(s) 2023. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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