Gut dysbiosis associates with cytokine production capacity in viral-suppressed people living with HIV.

Autor:	Zhang Y; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Andreu-Sánchez S; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Vadaq N; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands., Wang D; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Matzaraki V; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands., van der Heijden WA; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands., Gacesa R; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.; Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands., Weersma RK; Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands., Zhernakova A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Vandekerckhove L; HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital, Ghent, Belgium., de Mast Q; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands., Joosten LAB; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Netea MG; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany., van der Ven AJAM; Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands., Fu J; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Jazyk:	angličtina
Zdroj:	Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2023 Jul 31; Vol. 13, pp. 1202035. Date of Electronic Publication: 2023 Jul 31 (Print Publication: 2023).
DOI:	10.3389/fcimb.2023.1202035
Abstrakt:	Background: People living with human immunodeficiency virus (PLHIV) are exposed to chronic immune dysregulation, even when virus replication is suppressed by antiretroviral therapy (ART). Given the emerging role of the gut microbiome in immunity, we hypothesized that the gut microbiome may be related to the cytokine production capacity of PLHIV. Methods: To test this hypothesis, we collected metagenomic data from 143 ART-treated PLHIV and assessed the ex vivo production capacity of eight different cytokines [interleukin-1β (IL-1β), IL-6, IL-1Ra, IL-10, IL-17, IL-22, tumor necrosis factor, and interferon-γ] in response to different stimuli. We also characterized CD4 + T-cell counts, HIV reservoir, and other clinical parameters. Results: Compared with 190 age- and sex-matched controls and a second independent control cohort, PLHIV showed microbial dysbiosis that was correlated with viral reservoir levels (CD4 + T-cell-associated HIV-1 DNA), cytokine production capacity, and sexual behavior. Notably, we identified two genetically different P. copri strains that were enriched in either PLHIV or healthy controls. The control-related strain showed a stronger negative association with cytokine production capacity than the PLHIV-related strain, particularly for Pam3Cys-incuded IL-6 and IL-10 production. The control-related strain is also positively associated with CD4 + T-cell level. Conclusions: Our findings suggest that modulating the gut microbiome may be a strategy to modulate immune response in PLHIV. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Zhang, Andreu-Sánchez, Vadaq, Wang, Matzaraki, van der Heijden, Gacesa, Weersma, Zhernakova, Vandekerckhove, de Mast, Joosten, Netea, van der Ven and Fu.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu