Prospective study of e-cigarette use and respiratory symptoms in adolescents and young adults.

Autor:	Tackett AP; Department of Internal Medicine, Division of Medical Oncology, Center for Tobacco Research, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Urman R; Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA., Barrington-Trimis J; Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA., Liu F; Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA., Hong H; Division of Pulmonology, Children's Hospital of Orange County, Orange, California, USA., Pentz MA; Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA., Islam TS; Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA., Eckel SP; Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA., Rebuli M; Department of Pediatrics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA., Leventhal A; Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA., Samet JM; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado, USA., Berhane K; Department of Biostatistics, Columbia University, New York, New York, USA., McConnell R; Department of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA rmcconne@usc.edu.
Jazyk:	angličtina
Zdroj:	Thorax [Thorax] 2024 Jan 18; Vol. 79 (2), pp. 163-168. Date of Electronic Publication: 2024 Jan 18.
DOI:	10.1136/thorax-2022-218670
Abstrakt:	Rationale: Electronic cigarette (e-cigarette) aerosol contains volatile aldehydes, including flavourings and oxidant metals with known pulmonary toxicity. Objectives: To evaluate the associations of e-cigarette use with symptoms of wheeze, bronchitic symptoms and shortness of breath (SOB) across 4 years of prospective data. Methods: Participants completed questionnaires on respiratory symptoms and past 30-day e-cigarette, cigarette and cannabis use in 2014 (wave 1; N=2094; mean age 17.3 years, SD=0.6 years). Follow-up information was collected in 2015 (wave 2; n=1609), 2017 (wave 3; n=1502) and 2018 (wave 4; n=1637) using online surveys. Mixed-effects logistic regression models evaluated associations of e-cigarette use with respiratory symptoms. Measurements and Main Results: Participants were mostly Hispanic white (51.8%) and evenly representative by sex (49.6% female; 50.4% male). Compared with never e-cigarette users, past 30-day e-cigarette users reported increased odds of wheeze (OR 1.81; 95% CI 1.28, 2.56), bronchitic symptoms (OR 2.06; 95% CI 1.58, 2.69) and SOB (OR 1.78; 95% CI 1.23, 2.57), adjusting for study wave, age, sex, race, lifetime asthma diagnosis and parental education. Effect estimates were attenuated (wheeze (OR 1.41; 95% CI 0.99, 2.01), bronchitic symptoms (OR 1.55; 95% CI 1.18, 2.05), SOB (OR 1.48; 95% CI 1.01, 2.18)), after adjusting additionally for current cigarette use, cannabis use and secondhand exposure to e-cigarettes/cigarettes/cannabis. Conclusions: E-cigarette use in young adults was associated with respiratory symptoms, independent of combustible cannabis and cigarette exposures. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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