Diagnostic accuracy of eNose 'breathprints' for therapeutic drug monitoring of Tacrolimus trough levels in lung transplantation.

Autor: Wijbenga N; Department of Respiratory Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Erasmus MC Transplant Institute, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands., Muller MM; Department of Respiratory Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Educational program Technical Medicine; Leiden University Medical Center, Delft University of Technology & Erasmus University Medical Center, Rotterdam, The Netherlands.; Erasmus MC Transplant Institute, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands., Hoek RAS; Department of Respiratory Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Erasmus MC Transplant Institute, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands., Mathot BJ; Department of Respiratory Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Erasmus MC Transplant Institute, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands., Seghers L; Department of Respiratory Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Erasmus MC Transplant Institute, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands., Aerts JGJV; Department of Respiratory Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands., de Winter BCM; Department of Hospital Pharmacy, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands., Bos D; Department of Radiology & Nuclear Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands., Manintveld OC; Department of Cardiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Erasmus MC Transplant Institute, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands., Hellemons ME; Department of Respiratory Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Erasmus MC Transplant Institute, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Journal of breath research [J Breath Res] 2023 Sep 05; Vol. 17 (4). Date of Electronic Publication: 2023 Sep 05.
DOI: 10.1088/1752-7163/acf066
Abstrakt: In order to prevent long-term immunity-related complications after lung transplantation, close monitoring of immunosuppressant levels using therapeutic drug monitoring (TDM) is paramount. Novel electronic nose (eNose) technology may be a non-invasive alternative to the current invasive procedures for TDM. We investigated the diagnostic and categorization capacity of eNose breathprints for Tacrolimus trough blood plasma levels (TAC trough ) in lung transplant recipients (LTRs). We performed eNose measurements in stable LTR attending the outpatient clinic. We evaluated (1) the correlation between eNose measurements and TAC trough , (2) the diagnostic capacity of eNose technology for TAC trough , and (3) the accuracy of eNose technology for categorization of TAC trough into three clinically relevant categories (low: <7 µ g ml -1 , medium: 7-10 µ g ml -1 , and high: >10 µ g ml -1 ). A total of 186 measurements from 86 LTR were included. There was a weak but statistically significant correlation ( r = 0.21, p = 0.004) between the eNose measurements and TAC trough . The root mean squared error of prediction for the diagnostic capacity was 3.186 in the training and 3.131 in the validation set. The accuracy of categorization ranged between 45%-63% for the training set and 52%-69% in the validation set. There is a weak correlation between eNose breathprints and TAC trough in LTR. However, the diagnostic as well as categorization capacity for TAC trough using eNose breathprints is too inaccurate to be applicable in TDM.
(© 2023 IOP Publishing Ltd.)
Databáze: MEDLINE
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