[Comparative analysis of clinical characteristics, evolution and mortality of hospitalized patients with COVID-19 during the first and second wave of the pandemic (ECCOVID Study)].

Autor:	Córdova E; Hospital Cosme Argerich, Buenos Aires, Argentina. E-mail: dr_ecordova@hotmail.com., Mykietiuk A; Instituto Médico Platense, La Plata, Buenos Aires, Argentina., De Vedia L; Hospital F.J. Muñiz, Buenos Aires, Argentina., Bacelar B; Hospital Cosme Argerich, Buenos Aires, Argentina., Cáceres MF; Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires, Argentina., Nemirovsky C; Hospital Italiano de Buenos Aires, Argentina., Contreras R; Hospital Dr. Marcial V. Quiroga, San Juan, Argentina., Alzogaray MF; Instituto Médico Platense, La Plata, Buenos Aires, Argentina., Nannini E; Sanatorio Británico Rosario, Santa Fe, Argentina., Consalvo MF; Hospital Penna, Buenos Aires, Argentina., Soler Puy L; Hospital Julio C. Perrando, Resistencia, Chaco, Argentina., Scapellato PG; Hospital Santojanni, Buenos Aires, Argentina., Barcelona L; Hospital Prof. Dr. Bernardo A. Houssay, Vicente López, Buenos Aires, Argentina., Golikow ML; Hospital Nacional Posadas, El Palomar, Buenos Aires, Argentina., Piñeiro MF; Hospital Fernández, Buenos Aires, Argentina., Miño HJ; Hospital Iturraspe, Santa Fe, Argentina., Cabral M; Hospital Central Mendoza, Mendoza, Argentina., Lamponi Tappata L; Hospital Leónidas Lucero, Bahía Blanca, Buenos Aires, Argentina., Lopardo G; Hospital Prof. Dr. Bernardo A. Houssay, Vicente López, Buenos Aires, Argentina., Sued O; Organización Panamericana de la Salud (OPS), Washington DC, EE.UU., Stryjewski ME; Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires, Argentina.
Jazyk:	Spanish; Castilian
Zdroj:	Medicina [Medicina (B Aires)] 2023; Vol. 83 (4), pp. 551-557.
Abstrakt:	Introduction: Clinical features and outcomes of SARSCoV-2 infections may change between different waves of the pandemic. The objective of this study was to compare clinical characteristics and outcomes between two cohorts of patients hospitalized for COVID-19 during the first and second waves in Argentina. Methods: Multicenter and prospective registry of patients =18 years old with a confirmed diagnosis of COVID-19 admitted to 18 hospitals in Argentina during the first wave (March to October 2020) and second wave (March to July 2021) of the pandemic. Demographics, clinical characteristics, and outcomes of these patients were compared. Results: A total of 1691 patients were included (first wave n = 809, second wave n = 882). Hospitalized patients during the second wave were older (median 53 years vs. 61 years, p < 0.001), had more comorbidities (71% vs. 77%, p=0.007) and required more supplemental oxygen at admission (21% vs 62%, p < 0.001). During hospitalization, patients of the second wave required more supplemental oxygen (49% vs. 85%, p < 0.001), invasive ventilation (12% vs. 22%, p < 0.001) and had higher 30- day mortality (11% vs. 26%, p < 0.001). Comparing only patients who required supplemental oxygen during hospitalization, 30-day mortality was 20% and 30% p < 0.001 for the first and second wave, respectively. Conclusion: Compared to patients admitted during the first wave, patients admitted with SARS-CoV2 during the second wave in Argentina were more seriously ill and had a higher mortality.
Databáze:	MEDLINE
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