Adaptive Skills of Individuals with Angelman Syndrome Assessed Using the Vineland Adaptive Behavior Scales, 2nd Edition.

Autor: Gwaltney A; RTI International, Research Triangle Park, NC, USA., Potter SN; RTI International, Research Triangle Park, NC, USA., Peters SU; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA., Barbieri-Welge RL; Developmental Evaluation Clinic, Rady Children's Hospital-San Diego, San Diego, CA, USA., Horowitz LT; Greenwood Genetic Center, Greenwood, SC, USA., Noll LM; Texas Children's Hospital, Houston, TX, USA.; Baylor College of Medicine, Houston, TX, USA., Hundley RJ; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA., Bird LM; Division of Dysmorphology/Genetics, Rady Children's Hospital-San Diego, San Diego, CA, USA.; Department of Pediatrics, University of California San Diego, San Diego, CA, USA., Tan WH; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA., Sadhwani A; Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02446, USA. anjali.sadhwani@childrens.harvard.edu., Wheeler A; RTI International, Research Triangle Park, NC, USA.
Jazyk: angličtina
Zdroj: Journal of autism and developmental disorders [J Autism Dev Disord] 2024 Oct; Vol. 54 (10), pp. 3863-3887. Date of Electronic Publication: 2023 Aug 15.
DOI: 10.1007/s10803-023-06090-8
Abstrakt: In the current study, we examined adaptive skills and trajectories over time in 257 individuals with Angelman syndrome (AS) using the Vineland Adaptive Behavior Scales, 2nd Edition. Multilevel linear models were used to examine differences between molecular subtypes over time, from one year to 13 years of age, in the adaptive domains of communication, daily living skills, socialization and motor skills. Individuals with non-deletion subtypes typically demonstrated a higher level of adaptive skills compared to those with deletion subtypes. Statistically significant growth was observed in all adaptive domains through at least early adolescence. Individuals with AS should continue to receive developmental services and educational supports through adolescence and into adulthood given the slow rates of growth being observed across adaptive domains.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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