Biomimetic Approaches in Cardiac Tissue Engineering: Replicating the Native Heart Microenvironment.

Autor:	Khan A; Medicine, Dow University of Health Sciences, Karachi, PAK., Kumari P; Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK., Kumari N; Dow Medical College, Dow University of Health Sciences, Karachi, PAK., Shaikh U; Medicine, Dow University of Health Sciences, Karachi, PAK., Ekhator C; Neuro-Oncology, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, USA., Halappa Nagaraj R; Surgery, Avalon University School of Medicine, Willemstad, CUW., Yadav V; Internal Medicine, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, IND., Khan AW; Medicine, Jinnah Sindh Medical University, Karachi, PAK., Lazarevic S; Internal Medicine, University of Niš Faculty of Medicine, Niš, SRB., Bharati B; Internal Medicine, Nepal Medical College, Kathmandu, NPL., Lakshmipriya Vetrivendan G; Medicine, Karpaga Vinayaga Institute of Medical Sciences & Research Center, Kancheepuram, IND., Mulmi A; Medicine, TMSS Medical College, Bogura, BGD., Mohamed H; Medicine, United Nations Study & Understanding, The International Academy, Khartoum, SDN.; Medicine, Elrazi University, Khartoum, SDN., Ullah A; Internal Medicine, Mayo Hospital, Lahore, PAK., Kadel B; Internal Medicine, Nepal Medical College and Teaching Hospital, Kathmandu, NPL., Bellegarde SB; Pathology and Laboratory Medicine, American University of Antigua, St. John's, ATG., Rehman A; Surgery, Mayo Hospital, Lahore, PAK.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Aug 13; Vol. 15 (8), pp. e43431. Date of Electronic Publication: 2023 Aug 13 (Print Publication: 2023).
DOI:	10.7759/cureus.43431
Abstrakt:	Cardiovascular diseases, including heart failure, pose significant challenges in medical practice, necessitating innovative approaches for cardiac repair and regeneration. Cardiac tissue engineering has emerged as a promising solution, aiming to develop functional and physiologically relevant cardiac tissue constructs. Replicating the native heart microenvironment, with its complex and dynamic milieu necessary for cardiac tissue growth and function, is crucial in tissue engineering. Biomimetic strategies that closely mimic the natural heart microenvironment have gained significant interest due to their potential to enhance synthetic cardiac tissue functionality and therapeutic applicability. Biomimetic approaches focus on mimicking biochemical cues, mechanical stimuli, coordinated electrical signaling, and cell-cell/cell-matrix interactions of cardiac tissue. By combining bioactive ligands, controlled delivery systems, appropriate biomaterial characteristics, electrical signals, and strategies to enhance cell interactions, biomimetic approaches provide a more physiologically relevant environment for tissue growth. The replication of the native cardiac microenvironment enables precise regulation of cellular responses, tissue remodeling, and the development of functional cardiac tissue constructs. Challenges and future directions include refining complex biochemical signaling networks, paracrine signaling, synchronized electrical networks, and cell-cell/cell-matrix interactions. Advancements in biomimetic approaches hold great promise for cardiovascular regenerative medicine, offering potential therapeutic strategies and revolutionizing cardiac disease modeling. These approaches contribute to the development of more effective treatments, personalized medicine, and improved patient outcomes. Ongoing research and innovation in biomimetic approaches have the potential to revolutionize regenerative medicine and cardiac disease modeling by replicating the native heart microenvironment, advancing functional cardiac tissue engineering, and improving patient outcomes. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Khan et al.)
Databáze:	MEDLINE
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