Cellular profiling of a recently-evolved social behavior in cichlid fishes.

Autor: Johnson ZV; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA. zvjohns@emory.edu.; Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA. zvjohns@emory.edu.; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA. zvjohns@emory.edu.; Emory National Primate Research Center, Emory University, Atlanta, GA, USA. zvjohns@emory.edu., Hegarty BE; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA.; Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA., Gruenhagen GW; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA.; Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA., Lancaster TJ; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA.; Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA., McGrath PT; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA. patrick.mcgrath@biology.gatech.edu.; Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA. patrick.mcgrath@biology.gatech.edu., Streelman JT; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA. todd.streelman@biology.gatech.edu.; Institute of Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA. todd.streelman@biology.gatech.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Aug 14; Vol. 14 (1), pp. 4891. Date of Electronic Publication: 2023 Aug 14.
DOI: 10.1038/s41467-023-40331-9
Abstrakt: Social behaviors are diverse in nature, but it is unclear how conserved genes, brain regions, and cell populations generate this diversity. Here we investigate bower-building, a recently-evolved social behavior in cichlid fishes. We use single nucleus RNA-sequencing in 38 individuals to show signatures of recent behavior in specific neuronal populations, and building-associated rebalancing of neuronal proportions in the putative homolog of the hippocampal formation. Using comparative genomics across 27 species, we trace bower-associated genome evolution to a subpopulation of glia lining the dorsal telencephalon. We show evidence that building-associated neural activity and a departure from quiescence in this glial subpopulation together regulate hippocampal-like neuronal rebalancing. Our work links behavior-associated genomic variation to specific brain cell types and their functions, and suggests a social behavior has evolved through changes in glia.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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