Operant Training for Highly Palatable Food Alters Translating Messenger RNA in Nucleus Accumbens D 2 Neurons and Reveals a Modulatory Role of Ncdn.

Autor: Montalban E; Institut National de la Santé et de la Recherche Médicale Unite Mixte de Recherche-S 1270, Paris, France; Faculty of Sciences and Engineering, Sorbonne Université, Paris, France; Institut du Fer à Moulin, Paris, France. Electronic address: enrica.montalban@inrae.fr., Giralt A; Institut National de la Santé et de la Recherche Médicale Unite Mixte de Recherche-S 1270, Paris, France; Faculty of Sciences and Engineering, Sorbonne Université, Paris, France; Institut du Fer à Moulin, Paris, France., Taing L; Institut National de la Santé et de la Recherche Médicale Unite Mixte de Recherche-S 1270, Paris, France; Faculty of Sciences and Engineering, Sorbonne Université, Paris, France; Institut du Fer à Moulin, Paris, France., Nakamura Y; Institut National de la Santé et de la Recherche Médicale Unite Mixte de Recherche-S 1270, Paris, France; Faculty of Sciences and Engineering, Sorbonne Université, Paris, France; Institut du Fer à Moulin, Paris, France., Pelosi A; Institut National de la Santé et de la Recherche Médicale Unite Mixte de Recherche-S 1270, Paris, France; Faculty of Sciences and Engineering, Sorbonne Université, Paris, France; Institut du Fer à Moulin, Paris, France., Brown M; Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York., de Pins B; Institut National de la Santé et de la Recherche Médicale Unite Mixte de Recherche-S 1270, Paris, France; Faculty of Sciences and Engineering, Sorbonne Université, Paris, France; Institut du Fer à Moulin, Paris, France., Valjent E; Institut de Génomique Fonctionnelle, University of Montpellier, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Montpellier, France., Martin M; Eurecat, Centre Tecnològic de Catalunya, Unitat de Nutrició i Salut, Reus, Spain; Instituto de investigaciones médicas Hospital del Mar, Barcelona, Spain., Nairn AC; Department of Psychiatry, Yale School of Medicine, Connecticut Mental Health Center, New Haven, Connecticut., Greengard P; Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York., Flajolet M; Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York., Hervé D; Institut National de la Santé et de la Recherche Médicale Unite Mixte de Recherche-S 1270, Paris, France; Faculty of Sciences and Engineering, Sorbonne Université, Paris, France; Institut du Fer à Moulin, Paris, France., Gambardella N; aSciStance Ltd, Great Chesterford, United Kingdom., Roussarie JP; Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York., Girault JA; Institut National de la Santé et de la Recherche Médicale Unite Mixte de Recherche-S 1270, Paris, France; Faculty of Sciences and Engineering, Sorbonne Université, Paris, France; Institut du Fer à Moulin, Paris, France. Electronic address: jean-antoine.girault@inserm.fr.
Jazyk: angličtina
Zdroj: Biological psychiatry [Biol Psychiatry] 2024 May 15; Vol. 95 (10), pp. 926-937. Date of Electronic Publication: 2023 Aug 12.
DOI: 10.1016/j.biopsych.2023.08.006
Abstrakt: Background: Highly palatable food triggers behavioral responses including strong motivation. These effects involve the reward system and dopamine neurons, which modulate neurons in the nucleus accumbens (NAc). The molecular mechanisms underlying the long-lasting effects of highly palatable food on feeding behavior are poorly understood.
Methods: We studied the effects of 2-week operant conditioning of mice with standard or isocaloric highly palatable food. We investigated the behavioral responses and dendritic spine modifications in the NAc. We compared the translating messenger RNA in NAc neurons identified by the type of dopamine receptors they express, depending on the kind of food and training. We tested the consequences of invalidation of an abundant downregulated gene, Ncdn.
Results: Operant conditioning for highly palatable food increased motivation for food even in well-fed mice. In wild-type mice, free choice between regular and highly palatable food increased weight compared with access to regular food only. Highly palatable food increased spine density in the NAc. In animals trained for highly palatable food, translating messenger RNAs were modified in NAc neurons expressing dopamine D 2 receptors, mostly corresponding to striatal projection neurons, but not in neurons expressing D 1 receptors. Knockout of Ncdn, an abundant downregulated gene, opposed the conditioning-induced changes in satiety-sensitive feeding behavior and apparent motivation for highly palatable food, suggesting that downregulation may be a compensatory mechanism.
Conclusions: Our results emphasize the importance of messenger RNA alterations in D 2 striatal projection neurons in the NAc in the behavioral consequences of highly palatable food conditioning and suggest a modulatory contribution of Ncdn downregulation.
(Copyright © 2023 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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