Biocompatible zeolite-dye composites with anti-amyloidogenic properties.

Autor: Siposova K; Department of Biophysics, Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 04001, Kosice, Slovakia; College of Photonics, National Yang Ming Chiao Tung University, Tainan 711, Taiwan. Electronic address: siposova@saske.sk., Huntosova V; Center for Interdisciplinary Biosciences, Technology, and Innovation Park, P.J. Safarik University in Kosice, Jesenna 5, 041 54, Kosice, Slovakia. Electronic address: veronika.huntosova@upjs.sk., Sedlakova D; Department of Biophysics, Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 04001, Kosice, Slovakia. Electronic address: sedlakova@saske.sk., Macajova M; Institute of Animal Biochemistry and Genetics, Centre of Biosciences, Slovak Academy of Sciences, Dubravska cesta 9, 840 05 Bratislava, Slovakia. Electronic address: Mariana.Macajova@savba.sk., Bilcik B; Institute of Animal Biochemistry and Genetics, Centre of Biosciences, Slovak Academy of Sciences, Dubravska cesta 9, 840 05 Bratislava, Slovakia. Electronic address: Boris.Bilcik@savba.sk., Nair AV; College of Photonics, National Yang Ming Chiao Tung University, Tainan 711, Taiwan., Nair S; College of Photonics, National Yang Ming Chiao Tung University, Tainan 711, Taiwan., Hovhannisyan V; College of Photonics, National Yang Ming Chiao Tung University, Tainan 711, Taiwan. Electronic address: hovvlad@g2.nctu.edu.tw., Chen SJ; College of Photonics, National Yang Ming Chiao Tung University, Tainan 711, Taiwan. Electronic address: sheanjen@nctu.edu.tw., Musatov A; Department of Biophysics, Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 04001, Kosice, Slovakia. Electronic address: musatov@saske.sk.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2023 Nov 01; Vol. 251, pp. 126331. Date of Electronic Publication: 2023 Aug 12.
DOI: 10.1016/j.ijbiomac.2023.126331
Abstrakt: One of the most attractive approaches in biomedicine and pharmacy is the application of multifunctional materials. The mesoporous structure of clinoptilolite (CZ) absorbs various types of substances and can be used as a model for studying the carriers for targeted drug delivery with controlled release. CZ-dye composites are fabricated by incorporation into clinoptilolite pores commonly used dyes, aluminum phthalocyanine, zinc porphine, and hypericin. We examined and compared the effect of pure dyes and CZ-dye composites on insulin amyloidogenesis. The formation of insulin amyloid fibrils and the disassembly of preformed fibrils is significantly affected by any of the three compounds, however, the strongest effect is observed for aluminum phthalocyanine indicating a structurally-dependent anti-amyloidogenic activity of the dyes. The incorporation of dyes into CZ particles resulted in enhanced anti-amyloidogenic activity in comparison to pure CZ particles. The cell metabolic activity, biocompatibility and fluorescence biodistribution of the dyes entrapped in the composites were tested in vitro (U87 MG cells) and in vivo in the quail chorioallantoic membrane model. Considering the photoactive properties of the dyes used, we assume their applicability in photodiagnostics and photodynamic therapy. It can also be expected that their anti-amyloidogenic potential can be enhanced by photodynamic effect.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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