The relationship between diet, plasma glucose, and cancer prevalence across vertebrates.

Autor:	Kapsetaki SE; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, USA.; Center for Biocomputing, Security and Society, Biodesign Institute, Arizona State University, Tempe, AZ, USA.; Tufts University, School of Arts and Sciences, Department of Biology, Medford, MA, USA., Basile AJ; Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA.; School of Life Sciences, 427 East Tyler Mall, Arizona State University, Tempe, Arizona, USA., Compton ZT; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, USA.; Center for Biocomputing, Security and Society, Biodesign Institute, Arizona State University, Tempe, AZ, USA., Rupp SM; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, USA.; Center for Biocomputing, Security and Society, Biodesign Institute, Arizona State University, Tempe, AZ, USA., Duke EG; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, USA.; Department of Clinical Sciences, North Carolina State University, Raleigh, NC, 27607 USA.; Exotic Species Cancer Research Alliance, North Carolina State University, Raleigh, NC, 27607 USA., Boddy AM; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, USA.; Department of Anthropology, University of California Santa Barbara, CA, USA., Harrison TM; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, USA.; Department of Clinical Sciences, North Carolina State University, Raleigh, NC, 27607 USA.; Exotic Species Cancer Research Alliance, North Carolina State University, Raleigh, NC, 27607 USA., Sweazea KL; Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA.; College of Health Solutions, Arizona State University, Phoenix, AZ, USA., Maley CC; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, USA.; Center for Biocomputing, Security and Society, Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 02. Date of Electronic Publication: 2023 Aug 02.
DOI:	10.1101/2023.07.31.551378
Abstrakt:	Could diet and mean plasma glucose concentration (MPGluC) explain the variation in cancer prevalence across species? We collected diet, MPGluC, and neoplasia data for 160 vertebrate species from existing databases. We found that MPGluC negatively correlates with cancer and neoplasia prevalence, mostly of gastrointestinal organs. Trophic level positively correlates with cancer and neoplasia prevalence even after controlling for species MPGluC. Most species with high MPGluC (50/78 species = 64.1%) were birds. Most species in high trophic levels (42/53 species = 79.2%) were reptiles and mammals. Our results may be explained by the evolution of insulin resistance in birds which selected for loss or downregulation of genes related to insulin-mediated glucose import in cells. This led to higher MPGluC, intracellular caloric restriction, production of fewer reactive oxygen species and inflammatory cytokines, and longer telomeres contributing to longer longevity and lower neoplasia prevalence in extant birds relative to other vertebrates. Competing Interests: Competing interests We declare we do not have any conflicts of interest.
Databáze:	MEDLINE
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