A comprehensive workflow and its validation for simulating diffuse speckle statistics for optical blood flow measurements.

Autor:	Frisk LK; ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona), Spain., Verma M; ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona), Spain., Bešlija F; ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona), Spain., Lin CP; Department of Physics, Washington University in St. Louis, St. Louis, Missouri 63110, USA.; Department of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA., Patil N; ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona), Spain., Chetia S; ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona), Spain., Trobaugh J; Department of Electrical and Systems Engineering, Washington University School of Medicine, St. Louis, Missouri 63110, USA., Culver JP; Department of Physics, Washington University in St. Louis, St. Louis, Missouri 63110, USA.; Department of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA., Durduran T; ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona), Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 04. Date of Electronic Publication: 2023 Aug 04.
DOI:	10.1101/2023.08.03.551830
Abstrakt:	Diffuse optical methods including speckle contrast optical spectroscopy and tomography (SCOS and SCOT), use speckle contrast ( κ ) to measure deep blood flow. In order to design practical systems, parameters such as signal-to-noise ratio (SNR) and the effects of limited sampling of statistical quantities, should be considered. To that end, we have developed a method for simulating speckle contrast signals including effects of detector noise. The method was validated experimentally, and the simulations were used to study the effects of physical and experimental parameters on the accuracy and precision of κ . These results revealed that systematic detector effects resulted in decreased accuracy and precision of κ in the regime of low detected signals. The method can provide guidelines for the design and usage of SCOS and/or SCOT instruments.
Databáze:	MEDLINE
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