Intrinsic and environmental basis of aging: A narrative review.

Autor:	Navarro C; Endocrine and Metabolic Diseases Research Center. School of Medicine. University of Zulia. Maracaibo 4001, Venezuela., Salazar J; Endocrine and Metabolic Diseases Research Center. School of Medicine. University of Zulia. Maracaibo 4001, Venezuela., Díaz MP; Endocrine and Metabolic Diseases Research Center. School of Medicine. University of Zulia. Maracaibo 4001, Venezuela., Chacin M; Universidad Simón Bolívar, Facultad de Ciencias de la Salud, Barranquilla 080001, Colombia., Santeliz R; Endocrine and Metabolic Diseases Research Center. School of Medicine. University of Zulia. Maracaibo 4001, Venezuela., Vera I; Endocrine and Metabolic Diseases Research Center. School of Medicine. University of Zulia. Maracaibo 4001, Venezuela., D Marco L; Universidad Cardenal Herrera-CEU Medicine Department, CEU Universities, 46115 Valencia, Spain., Parra H; Endocrine and Metabolic Diseases Research Center. School of Medicine. University of Zulia. Maracaibo 4001, Venezuela., Bernal MC; Universidad Simón Bolívar, Facultad de Ingenierías, Cúcuta, Colombia., Castro A; Endocrine and Metabolic Diseases Research Center. School of Medicine. University of Zulia. Maracaibo 4001, Venezuela., Escalona D; Endocrine and Metabolic Diseases Research Center. School of Medicine. University of Zulia. Maracaibo 4001, Venezuela., García-Pacheco H; Universidad del Zulia, Facultad de Medicina, Departamento de Cirugía. Hospital General del Sur 'Dr. Pedro Iturbe'. Maracaibo, Venezuela.; Unidad de Cirugía para la Obesidad y Metabolismo (UCOM). Maracaibo, Venezuela., Bermúdez V; Universidad Simón Bolívar, Facultad de Ciencias de la Salud, Barranquilla 080001, Colombia.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2023 Jul 18; Vol. 9 (8), pp. e18239. Date of Electronic Publication: 2023 Jul 18 (Print Publication: 2023).
DOI:	10.1016/j.heliyon.2023.e18239
Abstrakt:	Longevity has been a topic of interest since the beginnings of humanity, yet its aetiology and precise mechanisms remain to be elucidated. Aging is currently viewed as a physiological phenomenon characterized by the gradual degeneration of organic physiology and morphology due to the passage of time where both external and internal stimuli intervene. The influence of intrinsic factors, such as progressive telomere shortening, genome instability due to mutation buildup, the direct or indirect actions of age-related genes, and marked changes in epigenetic, metabolic, and mitochondrial patterns constitute a big part of its underlying endogenous mechanisms. On the other hand, several psychosocial and demographic factors, such as diet, physical activity, smoking, and drinking habits, may have an even more significant impact on shaping the aging process. Consequentially, implementing dietary and exercise patterns has been proposed as the most viable alternative strategy for attenuating the most typical degenerative aging changes, thus increasing the likelihood of prolonging lifespan and achieving successful aging. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.)
Databáze:	MEDLINE
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