Pertinence of Streptococcus anginosus group in intracerebral abscesses in the era of extended antibiotic resistance.

Autor: Kavya S; Department of Neuromicrobiology, NIMHANS, India., Arvinda HR; Department of Neuro Imaging and Interventional Radiology, NIMHANS, India., Veenakumari HB; Department of Neuromicrobiology, NIMHANS, India., PrabuRaj AR; Department of Neurosurgery, NIMHANS, India., Smitha NR; Department of Neuromicrobiology, NIMHANS, India., Jyothi D; Department of Neuromicrobiology, NIMHANS, India., Dwarakanath S; Department of Neurosurgery, NIMHANS, India., Nagarathna S; Department of Neuromicrobiology, NIMHANS, India. Electronic address: nagarathnachandrashekar@gmail.com.
Jazyk: angličtina
Zdroj: Indian journal of medical microbiology [Indian J Med Microbiol] 2023 Sep-Oct; Vol. 45, pp. 100395. Date of Electronic Publication: 2023 Jun 09.
DOI: 10.1016/j.ijmmb.2023.100395
Abstrakt: Aims: • To study the incidence of Streptococcus anginosus group (SAG) in pyogenic or community acquired intra cerebral abscess. • To understand the risk factors for the same. • To analyze the specific radiological features and clinical outcome after surgery and antibiotic therapy.
Methods: This is a retrospective observational study of case series over a period of one year. Patients diagnosed with intracerebral abscess were included in the study. Pus collected from were received in the laboratory and processed according to the standard protocols. Data regarding the clinical findings and demographics were collected from medical records.
Findings: A total of 202 samples were studied. 103 were found to be pyogenic. SAG were isolated from 21 samples (20.38%) and all the isolates were sensitive to Penicillin. Age of the patients ranged from 18months to 68years. Male preponderance was noted with male to female ratio of 4:1. Otogenic infections were the most common predisposing factors and focus of infection could not be ascertained in 5 patients. All patients were treated with surgical intervention and antibiotics (Vancomycin, Amikacin and Metronidazole) for 6 weeks and recovery was remarkable. One patient succumbed to the illness.
Conclusion: SAG can be an aggressive pathogen with propensity for abscess formation. Chronic Suppurative Otitis Media (CSOM) is still a major cause of intracerebral abscess in developing country like India which is a benign and curable disease and should not be neglected. Injudicious use of antibiotics and negligence regarding the dose and duration of therapy from both patients and health care providers is the major cause for common infections to become more difficult to treat and succumbing to complications.
(Copyright © 2023 Indian Association of Medical Microbiologists. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: