Biological rhythms are correlated with Na + , K + -ATPase and oxidative stress biomarkers: A translational study on bipolar disorder.

Autor: Valvassori SS; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, The University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil. Electronic address: samiravalvassori@unesc.net., Peper-Nascimento J; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, The University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Aguiar-Geraldo JM; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, The University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Hilsendeger A; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, The University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Daminelli T; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, The University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Juruena MF; Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience-King's College London, London, UK., El-Mallakh RS; Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY, USA., Quevedo J; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, The University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil; Translational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; Center of Excellence on Mood Disorders, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2023 Nov 01; Vol. 340, pp. 877-885. Date of Electronic Publication: 2023 Aug 11.
DOI: 10.1016/j.jad.2023.08.042
Abstrakt: Background: Bipolar disorder (BD) is a chronic, severe, and multifactorial psychiatric disorder. Although biological rhythms alterations, sodium potassium pump (Na + , K + -ATPase) changes, and oxidative stress appear to play a critical role in the etiology and pathophysiology of BD, the inter-connection between them has not been described. Therefore this study evaluated the association between biological rhythms, Na + , K + -ATPase, and oxidative stress parameters in BD patients and the preclinical paradoxical sleep deprivation model (PSD).
Methods: A translational study was conducted, including a case-control protocol with 36 BD and 46 healthy controls (HC). Subjects completed the Biological Rhythm Interview of Assessment in Neuropsychiatry (BRIAN). In addition, Erythrocyte Na + , K + -ATPase activity, and oxidative and nitrosative stress markers were assessed (4-hydroxynonenal [4-HNE], 8-isoprostane [8-ISO], thiobarbituric acid reactive substances [TBARS], carbonyl, 3-nitrotyrosine [3-nitro]). In the preclinical protocol, the same biomarkers were evaluated in the frontal cortex, hippocampus, and striatum from mice submitted to the PSD.
Results: BD patients had a significantly higher total score of BRIAN versus HCs. Additionally, individuals with BD showed decreased Na + , K + -ATPase activity and increased oxidative stress parameters compared to HC without psychiatric disorders. This difference was driven by actively depressed BD subjects. The mice submitted to the PSD also demonstrated decreased Na + , K + -ATPase activity and increased oxidative stress parameters.
Limitations: BRIAN biological underpinning is less well characterized; We did not control for medication status; Sample size is limited; PSD it is not a true model of BD.
Conclusions: The present study found a significant correlation between Na + , K + -ATPase and oxidative stress with changes in biological rhythms, reinforcing the importance of these parameters to BD.
Competing Interests: Declaration of competing interest JQ received clinical research support from LivaNova; has speaker bureau membership with Myriad Neuroscience, Janssen Pharmaceuticals, and Abbvie; is consultant for Eurofarma; is stockholder at Instituto de Neurociencias Dr. Joao Quevedo; and receives copyrights from Artmed Editora, Artmed Panamericana, and Elsevier/Academic Press. MFJ is funded by the NIHR Biomedical Research Centre (BRC)at the South London and Maudsley (SLaM) NHS Foundation Trust and King’s College London and received honoraria for lectures and advisory boards from most of the major pharmaceutical companies with drugs used in affective and related disorders; and receives copyrights Nature/Springer Books, Cambridge Press, and Elsevier Press. The views expressed in this paper belong to the authors and not necessarily to the NHS, NIHR, or the Department of Health. REM has grant funding from Sunovion and is a speaker for Axsome, Intracellular, Janssen, Lundbeck, Myriad, Noven, Otsuka, and Teva.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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