Molecular mechanisms of long non-coding RNAs in differentiation of T Helper17 cells.

Autor: Saadh MJ; Faculty of Pharmacy, Middle East University, Amman 11831, Jordan; Applied Science Research Center. Applied Science Private University, Amman, Jordan. Electronic address: msaadeh@meu.edu.jo., Arellano MTC; Department of Civil Engineering, UNIVERSIDAD DE LIMA, Lima, Peru., Saini RS; Assoc Prof, COAMS, King Khalid University, Abha, Saudi Arabia. Electronic address: rsaini@kku.edu.sa., Amin AH; Deanship of Scientific Research, Umm Al-Qura University, Makkah 21955, Saudi Arabia. Electronic address: ahamin@uqu.edu.sa., Sharma N; Department of Computer Engineering & Application, GLA University, Mathura, India. Electronic address: aa@gla.ac.in., Arias-Gonzáles JL; Department of Social Science, Enfoques Consulting, Peru. Electronic address: a20225538@pucp.edu.pe., Alsandook T; Dentistry Department, Al-Turath University College, Baghdad, Iraq. Electronic address: tahany.abdulaziz@turath.edu.iq., Cotrina-Aliaga JC; Universidad Peruana de los Andes, Huancayo, Peru. Electronic address: juan.cotrina@upsjb.edu.pe., Akhavan-Sigari R; Department of Neurosurgery, University Medical Center Tuebingen, Germany; Department of Health Care Management and Clinical Research, Collegium Humanum Warsaw Management University Warsaw, Poland. Electronic address: reza.akhavan-sigari@pkd.de.
Jazyk: angličtina
Zdroj: International immunopharmacology [Int Immunopharmacol] 2023 Oct; Vol. 123, pp. 110728. Date of Electronic Publication: 2023 Aug 10.
DOI: 10.1016/j.intimp.2023.110728
Abstrakt: T helper (Th) 17 cells are one of the most important T cell subsets in a number of autoimmune and chronic inflammatory diseases. During infections, Th17 cells appear to play an important role in the clearance of extracellular pathogens. Th17 cells, on the other hand, are engaged in inflammation and have been linked to the pathophysiology of a number of autoimmune illnesses and human inflammatory disorders. A diverse group of RNA molecules known as lncRNAs serve critical functions in gene expression regulation. They may interact with a wide range of molecules, including DNA, RNA, and proteins, and have a complex structure. LncRNAs, which have restricted or no protein-coding activity, are implicated in a number of illnesses due to their regulatory impact on a variety of biological processes such as cell proliferation, apoptosis, and differentiation. Several lncRNAs have been associated with Th7 cell development in the context of immune cell differentiation. In this article, we cover new studies on the involvement of lncRNAs in Th17 cell differentiation in a variety of disorders, including auto-immune diseases, malignancies, asthma, heart disease, and infections.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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