Innate and Adaptive Immunity-Related Markers as Predictors of the Short-Term Progression of Subclinical Atherosclerosis in Middle-Aged Patients.

Autor: Genkel V; Federal State Budgetary Educational Institution of Higher Education 'South-Ural State Medical University' of the Ministry of Healthcare of the Russian Federation, 454092 Chelyabinsk, Russia., Dolgushin I; Federal State Budgetary Educational Institution of Higher Education 'South-Ural State Medical University' of the Ministry of Healthcare of the Russian Federation, 454092 Chelyabinsk, Russia., Savochkina A; Federal State Budgetary Educational Institution of Higher Education 'South-Ural State Medical University' of the Ministry of Healthcare of the Russian Federation, 454092 Chelyabinsk, Russia., Nikushkina K; Federal State Budgetary Educational Institution of Higher Education 'South-Ural State Medical University' of the Ministry of Healthcare of the Russian Federation, 454092 Chelyabinsk, Russia., Baturina I; Federal State Budgetary Educational Institution of Higher Education 'South-Ural State Medical University' of the Ministry of Healthcare of the Russian Federation, 454092 Chelyabinsk, Russia., Minasova A; Federal State Budgetary Educational Institution of Higher Education 'South-Ural State Medical University' of the Ministry of Healthcare of the Russian Federation, 454092 Chelyabinsk, Russia., Sumerkina V; Federal State Budgetary Educational Institution of Higher Education 'South-Ural State Medical University' of the Ministry of Healthcare of the Russian Federation, 454092 Chelyabinsk, Russia., Pykhova L; Federal State Budgetary Educational Institution of Higher Education 'South-Ural State Medical University' of the Ministry of Healthcare of the Russian Federation, 454092 Chelyabinsk, Russia., Kupriyanov S; Federal State Budgetary Educational Institution of Higher Education 'South-Ural State Medical University' of the Ministry of Healthcare of the Russian Federation, 454092 Chelyabinsk, Russia., Kuznetsova A; Federal State Budgetary Educational Institution of Higher Education 'South-Ural State Medical University' of the Ministry of Healthcare of the Russian Federation, 454092 Chelyabinsk, Russia., Shaposhnik I; Federal State Budgetary Educational Institution of Higher Education 'South-Ural State Medical University' of the Ministry of Healthcare of the Russian Federation, 454092 Chelyabinsk, Russia.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Jul 30; Vol. 24 (15). Date of Electronic Publication: 2023 Jul 30.
DOI: 10.3390/ijms241512205
Abstrakt: Assessment of inflammation is a promising approach to monitoring the progression of asymptomatic atherosclerosis. The aim of the present study was to investigate the predictive value of innate and adaptive immunity-related markers, in relation to the short-term progression of subclinical atherosclerosis. The study included 183 patients aged 40-64 years who underwent duplex scanning of the carotid and lower limb arteries at two visits with an interval of 12-24 months between examinations. Phenotyping of circulating lymphocytes and monocytes subpopulations were performed through flow cytometry. An increase in the number of circulating TLR4-positive intermediate monocytes (>447.0-467.0 cells/μL) was an independent predictor of the short-term progression of lower limb artery atherosclerosis ( p < 0.0001) and polyvascular atherosclerosis ( p = 0.003). The assessment of TLR4-positive monocytes significantly improved the prognostic model for the progression of lower limb arterial atherosclerosis (C-index 0.728 (0.642-0.815) versus 0.637 (0.539-0.735); p = 0.038). An increase in the number of circulating TLR4-positive intermediate monocytes was an independent predictor of the short-term progression of lower limb artery and polyvascular atherosclerosis. Their inclusion into models containing conventional risk factors significantly improved their prognostic effectiveness regarding lower limb artery atherosclerosis progression.
Databáze: MEDLINE
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