The C55A Single Nucleotide Polymorphism in CTLA-4 Gene, a New Possible Biomarker in Thyroid Autoimmune Pathology Such as Hashimoto's Thyroiditis.

Autor: Chiorean AD; Department of Cell and Molecular Biology, Faculty of Medicine, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.; Clinical Laboratory, Emergency Clinical Hospital for Children, 400370 Cluj-Napoca, Romania., Vica ML; Department of Cell and Molecular Biology, Faculty of Medicine, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.; Institute of Legal Medicine Cluj-Napoca, 400006 Cluj-Napoca, Romania., Bâlici Ș; Department of Cell and Molecular Biology, Faculty of Medicine, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania., Nicula GZ; Department of Cell and Molecular Biology, Faculty of Medicine, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania., Răcătăianu N; Integrated Ambulatory of Endocrinology, Infectious Diseases Clinical Hospital, 400000 Cluj-Napoca, Romania., Bordea MA; Department of Microbiology, Faculty of Medicine, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania., Simon LM; Department of Microbiology, Faculty of Medicine, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania., Matei HV; Department of Cell and Molecular Biology, Faculty of Medicine, 'Iuliu Hațieganu' University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.; Institute of Legal Medicine Cluj-Napoca, 400006 Cluj-Napoca, Romania.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2023 Jul 28; Vol. 13 (15). Date of Electronic Publication: 2023 Jul 28.
DOI: 10.3390/diagnostics13152517
Abstrakt: Hashimoto's thyroiditis (HT) is a chronic autoimmune disorder characterized by the production of autoantibodies against the thyroid gland. Different studies have shown that several genes may be associated with HT, which explains why patients often have family members with thyroiditis or other autoimmune diseases. The aim of this case-control study was to evaluate the correlation between polymorphisms at the level of exon 1 from the CTLA-4 gene and the susceptibility to developing HT. In this study, we found that there is no statistically significant association between the polymorphism rs231775 (A22G in exon 1) of the CTLA-4 gene and a genetic predisposition to HT. In contrast, a strong association was discovered for the first time between C55A in exon 1 of the CTLA-4 gene and HT. Our findings suggest that there is a genetic relationship between the CTLA-4 (+55A/C) genotype and the seropositivity against thyroid autoantigens, such as anti-thyroid peroxidase (ATPO) and anti-thyroglobulin antibodies (ATG).
Databáze: MEDLINE
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