Advancing Precision Medicine in Myocarditis: Current Status and Future Perspectives in Endomyocardial Biopsy-Based Diagnostics and Therapeutic Approaches.

Autor: Baumeier C; Institute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany., Harms D; Institute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.; Department of Infectious Diseases, Robert Koch Institute, 13353 Berlin, Germany., Aleshcheva G; Institute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany., Gross U; Institute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany., Escher F; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Virchow Klinikum, 13353 Berlin, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, 10785 Berlin, Germany., Schultheiss HP; Institute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2023 Jul 31; Vol. 12 (15). Date of Electronic Publication: 2023 Jul 31.
DOI: 10.3390/jcm12155050
Abstrakt: The diagnosis and specific and causal treatment of myocarditis and inflammatory cardiomyopathy remain a major clinical challenge. Despite the rapid development of new imaging techniques, endomyocardial biopsies remain the gold standard for accurate diagnosis of inflammatory myocardial disease. With the introduction and continued development of immunohistochemical inflammation diagnostics in combination with viral nucleic acid testing, myocarditis diagnostics have improved significantly since their introduction. Together with new technologies such as miRNA and gene expression profiling, quantification of specific immune cell markers, and determination of viral activity, diagnostic accuracy and patient prognosis will continue to improve in the future. In this review, we summarize the current knowledge on the pathogenesis and diagnosis of myocarditis and inflammatory cardiomyopathies and highlight future perspectives for more in-depth and specialized biopsy diagnostics and precision, personalized medicine approaches.
Competing Interests: The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje