Impact of SARS-CoV-2 on the clinical presentation of juvenile idiopathic inflammatory myopathies.

Autor: Perfetto J; Division of Rheumatology, The Children's Hospital at Montefiore, 3334 Bainbridge Avenue, Bronx, NY, 10467, USA. jperfetto@montefiore.org., Yoo DA; Albert Einstein College of Medicine, Bronx, NY, USA., Tamashiro CY; Department of Pediatrics, The Children's Hospital at Montefiore, Bronx, NY, USA., Perron MM; Division of Rheumatology, Children's Hospital Colorado, Aurora, CO, USA., Vasquez-Canizares N; Division of Rheumatology, The Children's Hospital at Montefiore, 3334 Bainbridge Avenue, Bronx, NY, 10467, USA., Wahezi DM; Division of Rheumatology, The Children's Hospital at Montefiore, 3334 Bainbridge Avenue, Bronx, NY, 10467, USA.
Jazyk: angličtina
Zdroj: Pediatric rheumatology online journal [Pediatr Rheumatol Online J] 2023 Aug 11; Vol. 21 (1), pp. 82. Date of Electronic Publication: 2023 Aug 11.
DOI: 10.1186/s12969-023-00861-4
Abstrakt: Background: Growing evidence suggests that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may trigger idiopathic inflammatory myopathies (IIM). Few studies have described individual juvenile IIM (JIIM) cases following SARS-CoV-2 infection, and none explored its potential effects on JIIM clinical presentation. We aim to investigate the impact of SARS-CoV-2 on JIIM in patients diagnosed before and after the onset of the Coronavirus Disease 2019 (COVID-19) pandemic.
Methods: Patients diagnosed with JIIM before age 19 at The Children's Hospital at Montefiore were included. Demographics, clinical and laboratory data, and evidence of SARS-CoV-2 exposure were collected retrospectively. Patients were grouped by pre-COVID-19 (before January 1, 2020) and post-COVID-19 (January 1, 2020, or later). Descriptive statistics were used to summarize each variable. Non-parametric testing was performed using Fischer's exact test and Mann-Whitney U test.
Results: Fifty-one patients were included, 13 (25%) diagnosed in the post-COVID-19 era. Of these, 10 (77%) had onset of JIIM symptoms after January 1, 2020; 6 (60%) with known or suspected SARS-CoV-2 exposure. Though not statistically significant, post-pandemic patients tended to be older, female, and have non-specific cutaneous manifestations. Despite reported delays in care for other pediatric diagnoses during the pandemic, fewer post-pandemic patients had delays in JIIM diagnosis.
Conclusions: This is the first study to explore the effects of SARS-CoV-2 on JIIM clinical presentation. While our exploratory single-center study did not find significant differences in JIIM diagnosed pre- and post-pandemic, larger prospective multicenter studies are warranted to evaluate this association and to explore clinical variances over time.
(© 2023. BioMed Central Ltd., part of Springer Nature.)
Databáze: MEDLINE
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