| Autor: |
Pandele AM; Advanced Polymer Materials Group, University Politehnica of Bucharest, 1-7 Gheorghe Polizu St., 011061, Bucharest, Romania.; Department of Analytical Chemistry and Environmental Engineering, University Politehnica of Bucharest, 1-7 Gheorghe Polizu St., 011061, Bucharest, Romania., Selaru A; Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095, Bucharest, Romania., Dinescu S; Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095, Bucharest, Romania., Costache M; Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095, Bucharest, Romania., Vasile E; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 1-7 Gheorghe Polizu St., 011061, Bucharest, Romania., Dascălu C; Department of Physics, University Politehnica of Bucharest, 313 Splaiul Independenţei, 060042, Bucharest, Romania., Raicopol MD; 'Costin Nenitzescu' Department of Organic Chemistry, University Politehnica of Bucharest, 1-7 Gheorghe Polizu St., 011061, Bucharest, Romania. m_raicopol@chim.upb.ro., Teodorescu M; Department of Bioresources and Polymer Science, University Politehnica of Bucharest, 1-7 Gheorghe Polizu St., 011061, Bucharest, Romania. |
| Abstrakt: |
In an effort to obtain porous scaffolds with improved mechanical properties and biocompatibility, the current study discusses nanocomposite materials based on poly(propylene fumarate)/ N -vinyl pyrrolidone(PPF/NVP) networks reinforced with polymer-modified graphene oxide (GO@PPF). The GO@PPF nanofiller was synthesized through a facile and convenient surface esterification reaction, and the successful functionalization was demonstrated by complementary techniques such as FT-IR, XPS, TGA and TEM. The PPF/NVP/GO@PPF porous scaffolds obtained using NaCl as a porogen were further characterized in terms of morphology, mechanical properties, sol fraction, and in vitro degradability. SEM and nanoCT examinations of NaCl-leached samples revealed networks of interconnected pores, fairly uniform in size and shape. We show that the incorporation of GO@PPF in the polymer matrix leads to a significant enhancement in the mechanical properties, which we attribute to the formation of denser and more homogenous networks, as suggested by a decreased sol fraction for the scaffolds containing a higher amount of GO@PPF. Moreover, the surface of mineralized PPF/NVP/GO@PPG scaffolds is uniformly covered in hydroxyapatite-like crystals having a morphology and Ca/P ratio similar to bone tissue. Furthermore, the preliminary biocompatibility assessment revealed a good interaction between PPF/PVP/GO@PPF scaffolds and murine pre-osteoblasts in terms of cell viability and proliferation. |
