Characterization of A/H7 influenza virus global antigenic diversity and key determinants in the hemagglutinin globular head mediating A/H7N9 antigenic evolution.

Autor:	Kok A; Department of Viroscience, Erasmus Medical Center , Rotterdam, The Netherlands., Scheuer R; Department of Viroscience, Erasmus Medical Center , Rotterdam, The Netherlands., Bestebroer TM; Department of Viroscience, Erasmus Medical Center , Rotterdam, The Netherlands., Burke DF; Center for Pathogen Evolution, Department of Zoology, University of Cambridge , Cambridge, United Kingdom., Wilks SH; Center for Pathogen Evolution, Department of Zoology, University of Cambridge , Cambridge, United Kingdom., Spronken MI; Department of Viroscience, Erasmus Medical Center , Rotterdam, The Netherlands., de Meulder D; Department of Viroscience, Erasmus Medical Center , Rotterdam, The Netherlands., Lexmond P; Department of Viroscience, Erasmus Medical Center , Rotterdam, The Netherlands., Pronk M; Department of Viroscience, Erasmus Medical Center , Rotterdam, The Netherlands., Smith DJ; Center for Pathogen Evolution, Department of Zoology, University of Cambridge , Cambridge, United Kingdom., Herfst S; Department of Viroscience, Erasmus Medical Center , Rotterdam, The Netherlands., Fouchier RAM; Department of Viroscience, Erasmus Medical Center , Rotterdam, The Netherlands., Richard M; Department of Viroscience, Erasmus Medical Center , Rotterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	MBio [mBio] 2023 Oct 31; Vol. 14 (5), pp. e0048823. Date of Electronic Publication: 2023 Aug 11.
DOI:	10.1128/mbio.00488-23
Abstrakt:	Importance: A/H7 avian influenza viruses cause outbreaks in poultry globally, resulting in outbreaks with significant socio-economical impact and zoonotic risks. Occasionally, poultry vaccination programs have been implemented to reduce the burden of these viruses, which might result in an increased immune pressure accelerating antigenic evolution. In fact, evidence for antigenic diversification of A/H7 influenza viruses exists, posing challenges to pandemic preparedness and the design of vaccination strategies efficacious against drifted variants. Here, we performed a comprehensive analysis of the global antigenic diversity of A/H7 influenza viruses and identified the main substitutions in the hemagglutinin responsible for antigenic evolution in A/H7N9 viruses isolated between 2013 and 2019. The A/H7 antigenic map and knowledge of the molecular determinants of their antigenic evolution add value to A/H7 influenza virus surveillance programs, the design of vaccines and vaccination strategies, and pandemic preparedness. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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