Ambient Temperature Effects on the Spring and Autumn Somatic Growth Trajectory Show Plasticity in the Photoneuroendocrine Response Pathway in the Tundra Vole.

Autor: van Dalum MJ; Arctic Seasonal Timekeeping Initiative, Department of Arctic and Marine Biology, UiT-the Arctic University of Norway, Tromsø, Norway., van Rosmalen L; Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.; The Salk Institute for Biological Studies, La Jolla, California., Appenroth D; Arctic Seasonal Timekeeping Initiative, Department of Arctic and Marine Biology, UiT-the Arctic University of Norway, Tromsø, Norway., Cazarez Marquez F; Arctic Seasonal Timekeeping Initiative, Department of Arctic and Marine Biology, UiT-the Arctic University of Norway, Tromsø, Norway., Roodenrijs RTM; Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands., de Wit L; Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands., Hut RA; Chronobiology Unit, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands., Hazlerigg DG; Arctic Seasonal Timekeeping Initiative, Department of Arctic and Marine Biology, UiT-the Arctic University of Norway, Tromsø, Norway.
Jazyk: angličtina
Zdroj: Journal of biological rhythms [J Biol Rhythms] 2023 Dec; Vol. 38 (6), pp. 586-600. Date of Electronic Publication: 2023 Aug 11.
DOI: 10.1177/07487304231190156
Abstrakt: Seasonal mammals register photoperiodic changes through the photoneuroendocrine system enabling them to time seasonal changes in growth, metabolism, and reproduction. To a varying extent, proximate environmental factors like ambient temperature (T a ) modulate timing of seasonal changes in physiology, conferring adaptive flexibility. While the molecular photoneuroendocrine pathway governing the seasonal responses is well defined, the mechanistic integration of nonphotoperiodic modulatory cues is poorly understood. Here, we explored the interaction between T a and photoperiod in tundra voles, Microtus oeconomus , a boreal species in which the main impact of photoperiod is on postnatal somatic growth. We demonstrate that postweaning growth potential depends on both gestational and postweaning patterns of photoperiodic exposure, with the highest growth potential seen in voles experiencing short (8 h) gestational and long (16 h) postweaning photoperiods-corresponding to a spring growth program. Modulation by T a was asymmetric: low T a (10 °C) enhanced the growth potential of voles gestated on short photoperiods independent of postweaning photoperiod exposure, whereas in voles gestated on long photoperiods, showing a lower autumn-programmed growth potential, the effect of T a was highly dependent on postweaning photoperiod. Analysis of the primary molecular elements involved in the expression of a neuroendocrine response to photoperiod, thyrotropin beta subunit ( tshβ ) in the pars tuberalis , somatostatin ( srif ) in the arcuate nucleus, and type 2/3 deiodinase ( dio2 / dio3 ) in the mediobasal hypothalamus identified dio2 as the most T a -sensitive gene across the study, showing increased expression at higher T a , while higher T a reduced somatostatin expression. Contrastingly dio3 and tshβ were largely insensitive to T a . Overall, these observations reveal a complex interplay between T a and photoperiodic control of postnatal growth in M. oeconomus , and suggest that integration of T a into the control of growth occurs downstream of the primary photoperiodic response cascade revealing potential adaptivity of small herbivores facing rising temperatures at high latitudes.
Competing Interests: Conflict of Interest StatementThe authors have no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze: MEDLINE
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