Synthesis of a novel hydrazone-based compound applied as a fluorescence turn-on chemosensor for iron(iii) and a colorimetric sensor for copper(ii) with antimicrobial, DFT and molecular docking studies.

Autor:	Rupa SA; Department of Chemistry, Comilla University Cumilla-3506 Bangladesh mamajedp@gmail.com., Patwary MAM; Department of Chemistry, Comilla University Cumilla-3506 Bangladesh mamajedp@gmail.com., Ghann WE; Center for Nanotechnology, Department of Natural Sciences, Coppin State University Baltimore USA., Abdullahi A; Center for Nanotechnology, Department of Natural Sciences, Coppin State University Baltimore USA., Uddin AKMR; Department of Chemistry, Comilla University Cumilla-3506 Bangladesh mamajedp@gmail.com., Mahmud MM; Tokushima University, Faculty of Pharmaceutical Science Tokushima Shi 770-0026 Japan., Haque MA; Department of Chemistry, Jagannath University Dhaka-1100 Bangladesh., Uddin J; Center for Nanotechnology, Department of Natural Sciences, Coppin State University Baltimore USA., Kazi M; Department of Pharmaceutics, College of Pharmacy, King Saud University P.O. Box 2457 Riyadh 11451 Saudi Arabia.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2023 Aug 09; Vol. 13 (34), pp. 23819-23828. Date of Electronic Publication: 2023 Aug 09 (Print Publication: 2023).
DOI:	10.1039/d3ra04364a
Abstrakt:	Hydrazone-hydrazide-based linkers perform a crucial role in environmental as well as biological fields. Such linkers are employed to detect exact metal ions at a minute level; hence, numerous probes are available. Even though thiophene-based molecules have a unique position in the medicinal arena, only very few chemosensors are reported based on such a moiety. In this current work, a novel hydrazide-hydrazone-based fluorogenic molecule 5-bromo-2-hydroxy- N '-[(1 E )-1-(thiophen-2-yl)ethylidene]benzohydrazide (L) has been successfully designed and synthesized. The sensing studies of L demonstrated a ratio metric as well as turn-on-enhanced fluorescence and colorimetric response toward Fe 3+ and Cu 2+ ions, respectively and it was observed to be insensitive toward various metal ions. The Job plots revealed that the binding stoichiometry of L and metal ions is 2 : 1. In addition, density functional theory (DFT) results strongly suggested that L can be used as a powerful colorimetric sensor for the detection of Cu 2+ ions. In vitro antimicrobial activities of L were evaluated by disk diffusion and results revealed good antibacterial activities against E. coli . Further, molecular docking was executed with DNA gyrase (PDB ID: 1KZN) of E. coli and the calculated interaction energy value was found to be -7.7 kcal mol -1 . Finally, molecular docking, fluorescence, colorimetry and the HOMO-LUMO energy gap of the compound can provide new insights into developing drugs and detecting metals in biomolecules. Competing Interests: The authors declare no competing financial interest. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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