Imaging surveillance in multiple endocrine neoplasia type 1: Ten years of experience with somatostatin receptor positron emission tomography.

Autor: Said M; Department of Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, Copenhagen N, Denmark., Krogh J; Department of Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, Copenhagen N, Denmark., Feldt-Rasmussen U; Department of Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, Copenhagen N, Denmark., Rasmussen ÅK; Department of Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, Copenhagen N, Denmark., Kristensen TS; Department of Radiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen N, Denmark., Rossing CM; Department of Genomic Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen N, Denmark., Johannesen HH; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen N, Denmark., Oturai P; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen N, Denmark., Holmager P; Department of Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, Copenhagen N, Denmark., Kjaer A; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen N, Denmark., Klose M; Department of Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, Copenhagen N, Denmark., Langer S; Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen N, Denmark., Knigge U; Department of Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, Copenhagen N, Denmark.; Department of surgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen N, Denmark., Andreassen M; Department of Endocrinology and Metabolism, Copenhagen University Hospital, Rigshospitalet, Copenhagen N, Denmark.
Jazyk: angličtina
Zdroj: Journal of neuroendocrinology [J Neuroendocrinol] 2023 Aug; Vol. 35 (8), pp. e13322. Date of Electronic Publication: 2023 Aug 11.
DOI: 10.1111/jne.13322
Abstrakt: Guidelines for multiple endocrine neoplasia type 1 (MEN1) recommend intensive imaging surveillance without specifying a superior regimen, including the role of somatostatin receptor imaging (SRI) with positron emission tomography (PET). The primary outcomes were to: (1) Assess change in treatment of duodenal-pancreatic neuroendocrine neoplasms (DP-NENs), bronchopulmonary NENs, and thymic tumors attributed to use of SRI PET/computed tomography (CT) and (2) estimate radiation from imaging and risk of cancer death attributed to imaging radiation. This was a retrospective single center study, including all MEN1 patients, who had had at least one SRI PET/CT. A total of 60 patients, median age 42 (range 21-54) years, median follow-up 6 (range 1-10) years were included. Of 470 cross sectional scans (MRI, CT, SRI PET/CT), 209 were SRI PET/CT. The additional information from SRI PET had implications in 1/14 surgical interventions and 2/12 medical interventions. The estimated median radiation dose per patient was 104 (range 51-468) mSv of which PET contributed with 13 (range 5-55) mSv and CT with 91 mSv (range 46-413 mSv), corresponding to an estimated increased median risk of cancer death of 0.5% during 6 years follow-up. SRI PET had a significant impact on 3/26 decisions to intervene in 60 MEN1 patients followed for a median of 6 years with SRI PET/CT as the most frequently used modality. The surveillance program showed a high radiation dose. Multi-modality imaging strategies designed to minimize radiation exposure should be considered. Based on our findings, SRI-PET combined with CT cannot be recommended for routine surveillance in MEN1 patients.
(© 2023 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.)
Databáze: MEDLINE
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