Antimicrobial Activity of Milk Whey in Different Mammals.

Autor: Kolyganova TI; Department of Microbiology, Virology, and Immunology, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia. tatianakolyganova@mail.ru.; I. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia. tatianakolyganova@mail.ru., Arzumanyan VG; I. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia., Matvienko MA; All-Russian Research Institute of Horse Breeding, Divovo, Rybnovsky district, Ryazan region, Russia., Rodionova AA; All-Russian Research Institute of Horse Breeding, Divovo, Rybnovsky district, Ryazan region, Russia., Korshunova DS; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia., Shatunova PO; Department of Microbiology, Virology, and Immunology, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.; I. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia., Yastrebova NE; I. I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Jul; Vol. 175 (3), pp. 358-361. Date of Electronic Publication: 2023 Aug 10.
DOI: 10.1007/s10517-023-05867-2
Abstrakt: Antimicrobial activity of milk whey in different mammals against Candida albicans yeast cells was studied by a spectrophotometric method. The activity increased in the order goat→horse→camel→cow→human→mouse. The level of whey activity in mice was higher by 3 and 10 times than in humans and goats, respectively. Similar changes were noted for activity of the whey fraction <100 kDa containing a complex of antimicrobial polypeptides, and there was a direct correlation between these two parameters (r=0.881; p<0.05). The total activity of whey had a high degree of correlation with the content of serum albumin (r=0.992); in mice, the level of serum albumin in the milk whey was close to that in blood serum. Interspecific differences between the activity of whey in mammals may be associated with qualitative and quantitative variability of the antimicrobial polypeptide composition, as well as their synergistic or antagonistic interaction with each other.
(© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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