High rate of adenovirus detection in gastrointestinal biopsies of symptomatic stem cell transplant recipients.

Autor: Pikkel-Geva HZ; Faculty of Medicine, the Hebrew University of Jerusalem, Jerusalem, Israel., Grisariu S; Faculty of Medicine, the Hebrew University of Jerusalem, Jerusalem, Israel.; Bone Marrow Transplantation and Cancer Immunotherapy Department, Hadassah University Medical Center, Jerusalem, Israel., Rivkin M; Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel., Stepensky P; Faculty of Medicine, the Hebrew University of Jerusalem, Jerusalem, Israel.; Bone Marrow Transplantation and Cancer Immunotherapy Department, Hadassah University Medical Center, Jerusalem, Israel., Strahilevitz J; Faculty of Medicine, the Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Clinical Microbiology and Infectious Diseases, Hadassah Medical Center, Jerusalem, Israel., Averbuch D; Faculty of Medicine, the Hebrew University of Jerusalem, Jerusalem, Israel.; Pediatric Infectious Diseases Unit, Faculty of Medicine, Hadassah Medical Center, Jerusalem, Israel., Orit C; Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel., Even-Or E; Faculty of Medicine, the Hebrew University of Jerusalem, Jerusalem, Israel.; Bone Marrow Transplantation and Cancer Immunotherapy Department, Hadassah University Medical Center, Jerusalem, Israel., Zaidman I; Faculty of Medicine, the Hebrew University of Jerusalem, Jerusalem, Israel.; Bone Marrow Transplantation and Cancer Immunotherapy Department, Hadassah University Medical Center, Jerusalem, Israel., Zimran E; Faculty of Medicine, the Hebrew University of Jerusalem, Jerusalem, Israel.; Bone Marrow Transplantation and Cancer Immunotherapy Department, Hadassah University Medical Center, Jerusalem, Israel., Wolf DG; Faculty of Medicine, the Hebrew University of Jerusalem, Jerusalem, Israel.; Clinical Virology Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel.; Department of Clinical Microbiology and Infectious Diseases, Hadassah Medical Center, Jerusalem, Israel., Avni B; Faculty of Medicine, the Hebrew University of Jerusalem, Jerusalem, Israel.; Bone Marrow Transplantation and Cancer Immunotherapy Department, Hadassah University Medical Center, Jerusalem, Israel.
Jazyk: angličtina
Zdroj: Clinical transplantation [Clin Transplant] 2023 Nov; Vol. 37 (11), pp. e15098. Date of Electronic Publication: 2023 Aug 10.
DOI: 10.1111/ctr.15098
Abstrakt: Objectives: The gastrointestinal (GI) tract is a major human adenovirus (HAdV) replication site in patients undergoing hematopoietic stem cell transplantation (HSCT), yet the prevalence and correlates of HAdV GI infection in this setting have remained poorly recognized, especially among adult HSCT recipients.
Design or Methods: We retrospectively studied the prevalence and risk factors of HAdV GI-tissue infection in HSCT recipients (73 adults and 15 children) with GI symptoms who underwent GI-tissue biopsy between January-2012 and December-2017. The presence of HAdV in the GI tissues was determined by real-time PCR.
Results: HAdV GI-tissue infection was detected in 21 (23.9%) patients, with similar infection rates identified in adults and children. GI-tissue detection was more common at late (>100 days) compared to early times post-transplantation (50% vs. 12.9%, p < .001). The presence of bloody diarrhea, Arab ethnicity (p = .014) and concurrent cytomegalovirus GI-tissue detection (p = .025) were significantly correlated with HAdV GI-tissue infection, while chronic graft versus host disease was of borderline association (p = .055).
Conclusions: Our findings reveal a high rate and new clinical-demographic correlates of HAdV GI-tissue infection in adult and pediatric HSCT recipients with GI symptoms. The findings highlight the need for future prospective studies to assess the relatedness of HAdV infection to the GI symptoms, and the prevalence, impact, and treatment of HAdV GI infection in HSCT recipients.
(© 2023 The Authors. Clinical Transplantation published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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