Gastrointestinal Dysfunction in Stroke.
| Autor: | Yong HYF; Department of Clinical Neurosciences, University of Calgary, Calgary, Canada.; Cumming School of Medicine, University of Calgary, Calgary, Canada., Ganesh A; Department of Clinical Neurosciences, University of Calgary, Calgary, Canada.; Cumming School of Medicine, University of Calgary, Calgary, Canada., Camara-Lemarroy C; Department of Clinical Neurosciences, University of Calgary, Calgary, Canada.; Cumming School of Medicine, University of Calgary, Calgary, Canada. |
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| Jazyk: | angličtina |
| Zdroj: | Seminars in neurology [Semin Neurol] 2023 Aug; Vol. 43 (4), pp. 609-625. Date of Electronic Publication: 2023 Aug 10. |
| DOI: | 10.1055/s-0043-1771470 |
| Abstrakt: | Gastrointestinal (GI) complications are seen in over 50% of ischemic stroke survivors; the most common complications are dysphagia, constipation, and GI bleeding. The bidirectional relationship of the gut-brain axis and stroke has recently gained traction, wherein stroke contributes to gut dysbiosis (alterations in the normal host intestinal microbiome) and gut dysbiosis perpetuates poor functional neurologic outcomes in stroke. It is postulated that the propagation of proinflammatory cells and gut metabolites (including trimethylamine N-oxide and short-chain fatty acids) from the GI tract to the central nervous system play a central role in gut-brain axis dysfunction. In this review, we discuss the known GI complications in acute ischemic stroke, our current knowledge from experimental stroke models for gut-brain axis dysfunction in stroke, and emerging therapeutics that target the gut-brain axis. Competing Interests: H.Y.F.Y. has nothing to disclose. A.G. reports consulting fees and honoraria from Atheneum, MD Analytics (Fig. 1), My Medical Panel, Creative Research Designs, CTC Communications Corp, AlphaSights, 42mr, Servier Canada, Alexion, and Biogen; research support from Alberta Innovates, Campus Alberta Neuroscience, the Canadian Cardiovascular Society, the University of Calgary (Hotchkiss Brain Institute), the Government of Canada INOVAIT program, the Heart and Stroke Foundation of Canada, the Alzheimer Society of Canada, and the Canadian Institutes of Health Research (CIHR); stock/stock options from Collavidence Inc, SnapDx Inc, and TheRounds.com; and a patent application (US 17/317,771) for a system for pre-hospital patient monitoring/assessment and delivery of remote ischemic conditioning or other cuff-based therapies, all outside of this work. C.C.-L. received consult fees from EMD Serono, outside of this work. (Thieme. All rights reserved.) |
| Databáze: | MEDLINE |
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