Bee venom ameliorates oxidative stress and histopathological changes of hippocampus, liver and testis during status epileptics.

Autor: Aly EK; Cell Biology & Histology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt., Mahmoud HS; Ecology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt., Alkhalifah DHM; Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia., Shehab GMG; Department of Biochemistry, College of Medicine, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia., Abuelsaad ASA; Immunology Division, Department of Zoology, Faculty of Science, Beni-Suef University, 62511 Beni-Suef, Egypt., Abdel-Rehiem ES; Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt., Abdul-Hamid M; Cell Biology & Histology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt. Electronic address: manal.mohamed3@science.bsu.edu.eg.
Jazyk: angličtina
Zdroj: Neuropeptides [Neuropeptides] 2023 Oct; Vol. 101, pp. 102368. Date of Electronic Publication: 2023 Aug 02.
DOI: 10.1016/j.npep.2023.102368
Abstrakt: The unrelenting progression of neurodegenerative diseases has a negative impact on affected individuals, their families, and society. Recurrent epileptic seizures are the hallmark of epilepsy, and treating it effectively remains difficult. Clarify and understanding effects of the antiepileptic drugs (AEDs) in epilepsy by comparing the therapeutic effects between rats receiving valproic acid (VPA) and Bee venom (BV) was aimed throughout the present study. Four male Wistar rat groups were included: control, epileptic group receiving pilocarpine (PILO), epileptic group treated with VPA and BV respectively. Cognitive functions were assessed by evaluating latency time in hot plate, despair swim test, grooming, rearing and ambulation frequency in the open field. BV has ameliorative effect on electrolytes balancing, assured by decreasing lipid peroxidation, nitric oxide and increasing catalase, superoxide dismutase and glutathione peroxidase activities. BV enhanced restoration of liver functions indicated by alanine transaminase (ALT) and aspartate transaminase (AST), total proteins, and albumin; hormonal parameters total and free testosterone, follicle stimulating hormone (FSH) and Luteinizing hormone (LH) were preserved by BV with great recovery of hippocampus, liver and testicular histopathology and ultrastructure comparing with the epileptic rats. The present findings suggested that BV and its active components offer fresh options for controlling epilepsy and prospective methods via minimize or manage the severe consequences.
Competing Interests: Declaration of Competing Interest The authors have not disclosed any competing interests.
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
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