Alzheimer's Behavioral and Psychiatric Burden in Saudi Arabia: Validation of the Saudi Version of the Neuropsychiatric Inventory.

Autor:	Tayeb HO; The Neuroscience Research Unit and the Mind and Brain Studies Initiative, Division of Neurology, Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah., Butt NS; The Faculty of Medicine in Rabigh, King Abdulaziz University, Rabigh., Khallaf R; Department of Neurology, Neuroscience Center, King Fahad Specialist Hospital Dammam., Yaghmoor B; The Neuroscience Research Unit and the Mind and Brain Studies Initiative, Division of Neurology, Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah., Basheikh MA; Division of Geriatrics Departments of Internal Medicine., Alamri SH; Family Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia., Baduwailan AO; The Neuroscience Research Unit and the Mind and Brain Studies Initiative, Division of Neurology, Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah., Alzaben F; Division of Psychiatry Internal Medicine., Abdulghaffar HK; The Neuroscience Research Unit and the Mind and Brain Studies Initiative, Division of Neurology, Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah., Koenig HG; Division of Psychiatry Internal Medicine.; Departments of Psychiatry and Behavioral Sciences.; Medicine, Duke University Medical Center, Durham, North Carolina.
Jazyk:	angličtina
Zdroj:	Alzheimer disease and associated disorders [Alzheimer Dis Assoc Disord] 2023 Jul-Sep 01; Vol. 37 (3), pp. 222-228. Date of Electronic Publication: 2023 Jun 26.
DOI:	10.1097/WAD.0000000000000563
Abstrakt:	Background: The burden of behavioral and psychiatric symptoms in dementia (BPSD) has not been characterized in Saudi patients with Alzheimer disease (AD). Moreover, the Saudi version of the Neuropsychiatric Inventory (SNPI) has not been validated. Objectives: The purpose of this study was to validate the SNPI and describe frequency and determinants of BPSD in Saudi AD patients. Methods: The SNPI and BEHAVE-AD instruments were administered to community-dwelling Saudi AD patients and their caregivers. Results: The sample size was 192. The first 59 constituted the validation cohort. Cronbach alpha of the SNPI and BEHAVE-AD were 0.91 and 0.79, respectively. There were significant correlations between: (1) the total SNPI and BEHAVE-AD scores ( r =0.84, P <0.001); (2) analogous SNPI and BEHAVE-AD symptom subscores ( P <0.05); (3) SNPI and BEHAVE-AD caregiver distress ( F =22.6, P <0.001). Inter-rater reliability of the SNPI was excellent (kappa=0.74). Ninety percent of patients experienced 4 SNPI symptoms or more. Patients with stroke and prior psychiatric history were most likely to experience BPSDs. The most common symptom was apathy (82%). Caregiver distress was determined by the total NPI score and impulsiveness subscale score. Conclusions: The SNPI is valid and reliable for assessing BPSD in Saudi AD patients. Longitudinal studies of BPSDs in Saudi specialized dementia clinics are needed. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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