| Autor: |
Li T; Department of Mechanical Engineering, National University of Singapore, 117575 Singapore., Liu Q; Department of Mechanical Engineering, National University of Singapore, 117575 Singapore., Cao J; Institute of Materials Research and Engineering (IMRE), A*STAR Agency for Science, Technology and Research, 138634 Singapore., Gan SW; NUS Centre for Additive Manufacturing, National University of Singapore, 117581 Singapore., Dong X; Department of Mechanical Engineering, National University of Singapore, 117575 Singapore., Yen CC; NUS Centre for Additive Manufacturing, National University of Singapore, 117581 Singapore., Wu C; State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences, Shanghai 200050, P. R. China., Zhai W; Department of Mechanical Engineering, National University of Singapore, 117575 Singapore. |
| Abstrakt: |
The emergence of nanosheet materials like graphene and phosphorene, which are created by breaking the interlayer van der Waals force, has revolutionized multiple fields. Layered inorganic materials are ubiquitous in materials like bioceramics, semiconductors, superconductors, etc. However, the strong interlayer covalent or ionic bonding in these crystals makes it difficult to fabricate nanosheets from them. In this study, we present a simple technique to produce nanosheets from layered crystals by selectively exfoliating their interlayer metal atoms using the metal-chelation reaction. As a proof of concept, we successfully produced bioceramic nanosheets (BCene) by extracting Ca layers from Akermanite (AKT). The 3D-printed BCene scaffolds exhibited superior mechanical strength and in vitro bioactivity compared to the scaffolds made from AKT nanopowders. Our findings demonstrate the outstanding potential of BCene nanosheets in tissue engineering. Additionally, the selective demetallization technique for nanosheet production could be applied to other inorganic layered crystals to optimize their performance. |
