Time separating spatial memories does not influence their integration in humans.

Autor: Fang X; Department of Psychology, University of Toronto, Toronto, Canada.; School of Psychology, Beijing Language and Culture University, Beijing, China., Alsbury-Nealy B; Department of Psychology, University of Toronto, Toronto, Canada., Wang Y; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada.; Department of Physiology, University of Toronto, Toronto, Canada., Frankland PW; Department of Psychology, University of Toronto, Toronto, Canada.; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada.; Department of Physiology, University of Toronto, Toronto, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Child & Brain Development Program, Canadian Institute for Advanced Research (CIFAR), Toronto, Canada., Josselyn SA; Department of Psychology, University of Toronto, Toronto, Canada.; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada.; Department of Physiology, University of Toronto, Toronto, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Schlichting ML; Department of Psychology, University of Toronto, Toronto, Canada., Duncan KD; Department of Psychology, University of Toronto, Toronto, Canada.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Aug 10; Vol. 18 (8), pp. e0289649. Date of Electronic Publication: 2023 Aug 10 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0289649
Abstrakt: Humans can navigate through similar environments-like grocery stores-by integrating across their memories to extract commonalities or by differentiating between each to find idiosyncratic locations. Here, we investigate one factor that might impact whether two related spatial memories are integrated or differentiated: Namely, the temporal delay between experiences. Rodents have been shown to integrate memories more often when they are formed within 6 hours of each other. To test if this effect influences how humans spontaneously integrate spatial memories, we had 131 participants search for rewards in two similar virtual environments. We separated these learning experiences by either 30 minutes, 3 hours, or 27 hours. Memory integration was assessed three days later. Participants were able to integrate and simultaneously differentiate related memories across experiences. However, neither memory integration nor differentiation was modulated by temporal delay, in contrast to previous work. We further showed that both the levels of initial memory reactivation during the second experience and memory generalization to novel environments were comparable across conditions. Moreover, perseveration toward the initial reward locations during the second experience was related positively to integration and negatively to differentiation-but again, these associations did not vary by delay. Our findings identify important boundary conditions on the translation of rodent memory mechanisms to humans, motivating more research to characterize how even fundamental memory mechanisms are conserved and diverge across species.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Fang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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