Hemophilus influenzae Infection's Association With Decreased Risk of Breast Cancer.

Autor:	Frankel LR; Nova Southeastern University, Dr. Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, FL, USA., Addanki S; Nova Southeastern University, Dr. Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, FL, USA., Ardeljan A; Nova Southeastern University, Dr. Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, FL, USA.; Department of Surgery, Michael and Dianne Biennes Comprehensive Cancer Center, Holy Cross Health, Fort Lauderdale, FL, USA., Takab K; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Department of Surgery, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, the State University of New York, Buffalo, NY, USA., Rashid OM; Nova Southeastern University, Dr. Kiran C. Patel College of Allopathic Medicine, Fort Lauderdale, FL, USA.; Department of Surgery, Michael and Dianne Biennes Comprehensive Cancer Center, Holy Cross Health, Fort Lauderdale, FL, USA.; University of Miami, Leonard Miami School of Medicine, Miami, FL, USA.; Department of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USA.; Department of Surgical Oncology, Broward Health, Fort Lauderdale, FL, USA.; TopLine MD Alliance, Fort Lauderdale, FL, USA.; Department of Surgical Oncology Memorial Health, Pembroke Pines, FL, USA.; Department of Surgical Oncology, Delray Medical Center, Delray, FL, USA.
Jazyk:	angličtina
Zdroj:	World journal of oncology [World J Oncol] 2023 Aug; Vol. 14 (4), pp. 255-265. Date of Electronic Publication: 2023 Aug 04.
DOI:	10.14740/wjon1617
Abstrakt:	Background: Hemophilus influenzae ( H. influenzae ) is a common cause of widespread bacterial infections and has been associated with the stabilization of the microbiome. The microbiome, through modulating systemic inflammation with possible upregulation of the NLRP3 inflammasome, may potentiate the development of breast cancer (BC). The purpose of this study was to therefore evaluate the correlation between previous H. influenzae infection and the incidence of BC. Methods: A large national database was used to collect International Classification of Disease Ninth and Tenth Codes to evaluate the incidence of BC between January 2010 and December 2019 in patients with and without H. influenzae history. A retrospective cohort study was performed where these groups of individuals were matched by age range, Charlson Comorbidity Index (CCI), and antibiotic treatment exposure. Significance and relative risk were obtained using standard statistical procedures. Results: A total of 13,599 patients were matched by age range and CCI in both the experimental and control groups. BC incidence was 259 (1.905%) in the H. influenzae group compared to 686 (5.044%) in the control group (P < 2.2 × 10 -16 ; odds ratio (OR) = 0.604, 95% confidence interval (CI): 0.553 - 0.660). Matching by antibiotic treatment exposure resulted in two groups of 3,189 patients, in which BC incidence was 98 (3.073 %) in the H. influenzae group compared to 171 (5.362%) in the control group (P < 2.2 × 10 -16 ; OR = 0.584, 95% CI: 0.515 - 0.661). Conclusion: The study shows a statistically significant correlation between H. influenzae and a reduced incidence of BC. These results warrant further research regarding H. influenzae 's role in upregulating the NLRP3 inflammasome and its potential role in BC prevention and treatment. Competing Interests: None to declare. (Copyright 2023, Frankel et al.)
Databáze:	MEDLINE
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