Enteral Feeding and Antibiotic Treatment Do Not Influence Increased Coefficient of Variation of Total Fecal Bile Acids in Necrotizing Enterocolitis.

Autor:	Rothers JL; BIO5 Institute Statistics Consulting Lab, University of Arizona, Tucson, Arizona, United States of America., Calton CM; Department of Pediatrics, University of Arizona College of Medicine, Tucson, Arizona, United States of America., Stepp JM; Department of Family and Community Medicine, University of Arizona College of Medicine, Tucson, Arizona, United States of America., Halpern MD; Department of Pediatrics, University of Arizona College of Medicine, Tucson, Arizona, United States of America.
Jazyk:	angličtina
Zdroj:	Newborn (Clarksville, Md.) [Newborn (Clarksville)] 2023; Vol. 2 (2), pp. 128-132. Date of Electronic Publication: 2023 May 07.
DOI:	10.5005/jp-journals-11002-0063
Abstrakt:	Introduction: Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in preterm infants. In animal models, the accumulation of ileal bile acids (BAs) is a crucial component of NEC pathophysiology. Recently, we showed that the coefficient of variation of total fecal BAs (CV-TBA) was elevated in infants who develop NEC compared to matched controls. However, neither the type of enteral nutrition nor antibiotic treatments-parameters that could potentially influence BA levels-were used to match pairs. Thus, we assessed the relationships between exposure to enteral feeding types and antibiotic treatments with NEC status and CV-TBA. Materials and Methods: Serial fecal samples were collected from 79 infants born with birth weight (BW) ≤1800 gm and estimated gestational age (EGA) ≤32 weeks; eighteen of these infants developed NEC. Total fecal BA levels (TBA) were determined using a commercially available enzyme cycling kit. Relationships between CV-TBA and dichotomous variables (NEC status, demographics, early exposure variables) were assessed by independent samples t-tests. Fisher's exact tests were used to assess relationships between NEC status and categorical variables. Results: High values for CV-TBA levels perfectly predicted NEC status among infants in this study. However, feeding type and antibiotic usage did not drive this relationship. Conclusions: As in previous studies, high values for the CV-TBA levels in the first weeks of life perfectly predicted NEC status among infants. Importantly, feeding type and antibiotic usage-previously identified risk factors for NEC-did not drive this relationship. Competing Interests: Conflict of interest: None
Databáze:	MEDLINE
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