A smartphone-based application for cough counting in patients with acute asthma exacerbation.

Autor:	Shim JS; Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Republic of Korea., Kim BK; Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea., Kim SH; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Kwon JW; Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Republic of Korea., Ahn KM; Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea., Kang SY; Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Republic of Korea., Park HK; Department of Allergy and Clinical Immunology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea., Park HW; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Yang MS; Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea., Kim MH; Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Republic of Korea., Lee SM; Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Republic of Korea.
Jazyk:	angličtina
Zdroj:	Journal of thoracic disease [J Thorac Dis] 2023 Jul 31; Vol. 15 (7), pp. 4053-4065. Date of Electronic Publication: 2023 Jun 09.
DOI:	10.21037/jtd-22-1492
Abstrakt:	Background: While tools exist for objective cough counting in clinical studies, there is no available tool for objective cough measurement in clinical practice. An artificial intelligence (AI)-based cough count system was recently developed that quantifies cough sounds collected through a smartphone application. In this prospective study, this AI-based cough algorithm was applied among real-world patients with an acute exacerbation of asthma. Methods: Patients with an acute asthma exacerbation recorded their cough sounds for 7 days (2 consecutive hours during awake time and 5 consecutive hours during sleep) using Coughy TM smartphone application. During the study period, subjects received systemic corticosteroids and bronchodilator to control asthma. Coughs collected by application were counted by both the AI algorithm and two human experts. Subjects also provided self-measured peak expiratory flow rate (PEFR) and completed other outcome assessments [e.g., cough symptom visual analogue scale (CS-VAS), awake frequency, salbutamol use] to investigate the correlation between cough and other parameters. Results: A total of 1,417.6 h of cough recordings were obtained from 24 asthmatics (median age =39 years). Cough counts by AI were strongly correlated with manual cough counts during sleep time (rho =0.908, P<0.001) and awake time (rho =0.847, P<0.001). Sleep time cough counts were moderately to strongly correlated with CS-VAS (rho =0.339, P<0.001), the frequency of waking up (rho =0.462, P<0.001), and salbutamol use at night (rho =0.243, P<0.001). Weak-to-moderate correlations were found between awake time cough counts and CS-VAS (rho =0.313, P<0.001), the degree of activity limitation (rho =0.169, P=0.005), and salbutamol use at awake time (rho =0.276, P<0.001). Neither awake time nor sleep time cough counts were significantly correlated with PEFR. Conclusions: The strong correlation between cough counts using the AI-based algorithm and human experts, and other indicators of patient health status provides evidence of the validity of this AI algorithm for use in asthma patients experiencing an acute exacerbation. Study findings suggest that Coughy TM could be a novel solution for objectively monitoring cough in a clinical setting. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-22-1492/coif). The series “Novel Insights into Chronic Cough” was commissioned by the editorial office without any funding or sponsorship. The authors have no other conflicts of interest to declare. (2023 Journal of Thoracic Disease. All rights reserved.)
Databáze:	MEDLINE
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