Obesity-Related Hypogonadism in Women.

Autor: Eng PC; Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK.; Department of Endocrinology, National University of Singapore, Singapore 117549., Phylactou M; Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK.; Department of Endocrinology, Imperial College Healthcare NHS Trust, London W12 0NN, UK., Qayum A; Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK.; Department of Endocrinology, Imperial College Healthcare NHS Trust, London W12 0NN, UK., Woods C; Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK., Lee H; Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK., Aziz S; Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK., Moore B; Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK., Miras AD; Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK.; Department of Endocrinology, Imperial College Healthcare NHS Trust, London W12 0NN, UK., Comninos AN; Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK.; Department of Endocrinology, Imperial College Healthcare NHS Trust, London W12 0NN, UK., Tan T; Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK.; Department of Endocrinology, Imperial College Healthcare NHS Trust, London W12 0NN, UK., Franks S; Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK.; Department of Endocrinology, Imperial College Healthcare NHS Trust, London W12 0NN, UK., Dhillo WS; Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK.; Department of Endocrinology, Imperial College Healthcare NHS Trust, London W12 0NN, UK., Abbara A; Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK.; Department of Endocrinology, Imperial College Healthcare NHS Trust, London W12 0NN, UK.
Jazyk: angličtina
Zdroj: Endocrine reviews [Endocr Rev] 2024 Mar 04; Vol. 45 (2), pp. 171-189.
DOI: 10.1210/endrev/bnad027
Abstrakt: Obesity-related hypogonadotropic hypogonadism is a well-characterized condition in men (termed male obesity-related secondary hypogonadism; MOSH); however, an equivalent condition has not been as clearly described in women. The prevalence of polycystic ovary syndrome (PCOS) is known to increase with obesity, but PCOS is more typically characterized by increased gonadotropin-releasing hormone (GnRH) (and by proxy luteinizing hormone; LH) pulsatility, rather than by the reduced gonadotropin levels observed in MOSH. Notably, LH levels and LH pulse amplitude are reduced with obesity, both in women with and without PCOS, suggesting that an obesity-related secondary hypogonadism may also exist in women akin to MOSH in men. Herein, we examine the evidence for the existence of a putative non-PCOS "female obesity-related secondary hypogonadism" (FOSH). We précis possible underlying mechanisms for the occurrence of hypogonadism in this context and consider how such mechanisms differ from MOSH in men, and from PCOS in women without obesity. In this review, we consider relevant etiological factors that are altered in obesity and that could impact on GnRH pulsatility to ascertain whether they could contribute to obesity-related secondary hypogonadism including: anti-Müllerian hormone, androgen, insulin, fatty acid, adiponectin, and leptin. More precise phenotyping of hypogonadism in women with obesity could provide further validation for non-PCOS FOSH and preface the ability to define/investigate such a condition.
(© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.)
Databáze: MEDLINE
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