Phytochemistry, antioxidant, anticancer, and acute toxicity of traditional medicinal food Biarum bovei (Kardeh).
| Autor: | Wahab BAA; Department of Physiology, Biochemistry & Pharmacology, Faculty of Vet Medicine, University of Kufa, Kufa, Iraq., Alamri ZZ; Department of Biology, College of Science, University of Jeddah, Jeddah, Saudi Arabia., Jabbar AAJ; Department of Medical Laboratory Technology, Erbil Technical Health and Medical College, Erbil Polytechnic University, Erbil, 44001, Iraq. ahmed.abuljabbar@epu.edu.iq., Ibrahim IAA; Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Almaimani RA; Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia., Almasmoum HA; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia., Ghaith MM; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia., Farrash WF; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia., Almutawif YA; Department of Medical Laboratories Technology, College of Applied Medical Sciences, Taibah University, Madinah, 42353, Saudi Arabia., Ageeli KA; Department of Pharmacy, Faculty of Pharmacy, Jazan University, Jizan, Saudi Arabia., Alfaifi SM; Department of Pharmacy, Faculty of Pharmacy, Jazan University, Jizan, Saudi Arabia., Alharthi RF; Department of Biology, College of Science, University of Jeddah, Jeddah, Saudi Arabia. |
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| Jazyk: | angličtina |
| Zdroj: | BMC complementary medicine and therapies [BMC Complement Med Ther] 2023 Aug 09; Vol. 23 (1), pp. 283. Date of Electronic Publication: 2023 Aug 09. |
| DOI: | 10.1186/s12906-023-04080-y |
| Abstrakt: | Background: The Biarum species (Kardeh) has been consumed as a traditional functional food and medicine for decades. The current study investigates the phytochemistry, in-vitro and in-vivo bioactivities of methanol extracts of B. bovei. Methods: The Gas-chromatography mass spectrophotometer (GS/GS-MS) was used to analyze the phytochemical profile of the methanol extracts of B. bovei leaves and corms. The B. bovei extracts (BBE) were also investigated for in-vitro antioxidant, anticancer, and in-vivo acute toxicity (2000 mg/kg) activities. Results: The chemical profiling of BBE revealed mainly fatty acids, phytosterol, alcohols, and hydrocarbon compounds. Namely, Linoleic acid, eliadic acid, palmitic acid, 22,23-dihydro-stigmasterol, and campesterol. The antioxidant activity of BBE ranged between 0.24-3.85 μg TE/mL based on different assays. The extracts also exhibited significant anticancer activity against DU-145 (prostate cancer cells), MCF-7 (human breast adenocarcinoma), and HeLa (human cervical cancer) cell lines with IC Conclusion: The detected phytochemicals and bioactivities of BBE scientifically backup the folkloric usage as an important source of nutraceuticals and alternative medicine for oxidative stress-related diseases and carcinogenesis inhibition. (© 2023. BioMed Central Ltd., part of Springer Nature.) |
| Databáze: | MEDLINE |
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