Effect of intraperitoneal magnesium sulfate in the prevention of postoperative pain in daycare laparoscopic cholecystectomy - A prospective randomized controlled trial.

Autor: Sravanthi GC; Department of Surgery, PGIMER, Chandigarh, India., Abuji K; Department of Surgery, PGIMER, Chandigarh, India., Soni SL; Department of Anaesthesia and Critical Care, PGIMER, Chandigarh, India., Nagaraj SS; Department of Surgery, PGIMER, Chandigarh, India., Sharma A; Department of Psychiatry, PGIMER, Chandigarh, India., Jafra A; Department of Anaesthesia and Critical Care, PGIMER, Chandigarh, India., Tandup C; Department of Surgery, PGIMER, Chandigarh, India., Kurdia KC; Department of Surgery, PGIMER, Chandigarh, India., Dahiya D; Department of Surgery, PGIMER, Chandigarh, India.
Jazyk: angličtina
Zdroj: Indian journal of pharmacology [Indian J Pharmacol] 2023 May-Jun; Vol. 55 (3), pp. 174-178.
DOI: 10.4103/ijp.ijp_827_22
Abstrakt: This study evaluated the efficacy of intraperitoneal magnesium sulfate (MgSO 4 ) in preventing postoperative pain after elective laparoscopic cholecystectomy (LC). It is a prospective, double-blinded, placebo-controlled, randomized trial which included 64 patients who underwent LC. Patients were equally randomized into Groups A and B. MgSO 4 and normal saline were instilled in subdiaphragmatic space in Groups A and B, respectively, after creating pneumoperitoneum and before starting dissection. The Visual analogue Scale (VAS) was used to determine postoperative pain. Patients who received intraperitoneal MgSO 4 had lower average VAS scores for the first 6 h postoperatively, and also, the time for the requirement of first analgesic was longer (3.6 ± 0.4 vs. 2.3 ± 1.0 h). The incidence of vomiting and the requirement for rescue antiemetic was also lower in Group A. Intraperitoneal instillation of MgSO 4 reduces postoperative pain and vomiting following elective LC without incurring additional side effects.
Competing Interests: None
Databáze: MEDLINE
Externí odkaz: