Three specific gut bacteria in the occurrence and development of colorectal cancer: a concerted effort.
| Autor: | Gong D; Institute of Zoonosis, College of Public Health, Zunyi Medical University, Zunyi, Guizhou, China., Adomako-Bonsu AG; Institute of Toxicology and Pharmacology, University Medical School Schleswig-Holstein, Kiel, Germany., Wang M; Gastrointestinal Surgery, Affiliate Hospital of Zunyi Medical University, Zunyi, Guizhou, China., Li J; Institute of Zoonosis, College of Public Health, Zunyi Medical University, Zunyi, Guizhou, China. |
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| Jazyk: | angličtina |
| Zdroj: | PeerJ [PeerJ] 2023 Aug 04; Vol. 11, pp. e15777. Date of Electronic Publication: 2023 Aug 04 (Print Publication: 2023). |
| DOI: | 10.7717/peerj.15777 |
| Abstrakt: | Colorectal cancer (CRC), which develops from the gradual evolution of tubular adenomas and serrated polyps in the colon and rectum, has a poor prognosis and a high mortality rate. In addition to genetics, lifestyle, and chronic diseases, intestinal integrity and microbiota (which facilitate digestion, metabolism, and immune regulation) could promote CRC development. For example, enterotoxigenic Bacteroides fragilis , genotoxic Escherichia coli (pks+ E. coli) , and Fusobacterium nucleatum , members of the intestinal microbiota, are highly correlated in CRC. This review describes the roles and mechanisms of these three bacteria in CRC development. Their interaction during CRC initiation and progression has also been proposed. Our view is that in the precancerous stage of colorectal cancer, ETBF causes inflammation, leading to potential changes in intestinal ecology that may provide the basic conditions for pks+ E. coli colonization and induction of oncogenic mutations, when cancerous intestinal epithelial cells can further recruit F. nucleatum to colonise the lesion site and F. nucleatum may contribute to CRC advancement by primarily the development of cancer cells, stemization, and proliferation, which could create new and tailored preventive, screening and therapeutic interventions. However, there is the most dominant microbiota in each stage of CRC development, not neglecting the possibility that two or even all three bacteria could be engaged at any stage of the disease. The relationship between the associated gut microbiota and CRC development may provide important information for therapeutic strategies to assess the potential use of the associated gut microbiota in CRC studies, antibiotic therapy, and prevention strategies. Competing Interests: The authors declare that they have no competing interests. (© 2023 Gong et al.) |
| Databáze: | MEDLINE |
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