The strict regulation of HIF-1α by non-coding RNAs: new insight towards proliferation, metastasis, and therapeutic resistance strategies.

Autor: Jawad SF; Department of Pharmacy, Al-Mustaqbal University College, Hilla, Babylon, 51001, Iraq., Altalbawy FMA; National Institute of Laser Enhanced Sciences, University of Cairo, Giza, 12613, Egypt.; Department of Chemistry, University College of Duba, University of Tabuk, Tabuk, Saudi Arabia., Hussein RM; College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq., Fadhil AA; College of Medical Technology, Medical Lab Techniques, Al-Farahidi University, Baghdad, Iraq., Jawad MA; Department of Medical Laboratories Technology, Al-Nisour University College, Baghdad, Iraq., Zabibah RS; Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq., Taraki TY; Department of Dentistry, AlNoor University College, Nineveh, Iraq., Mohan CD; Department of Studies in Molecular Biology, University of Mysore, Manasagangotri, Mysore, 570006, India. cd.mohan@iitr.res.in.; FEST Division, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, 226 001, India. cd.mohan@iitr.res.in., Rangappa KS; Institution of Excellence, Vijnana Bhavan, University of Mysore, Manasagangotri, Mysore, 570006, India. rangappaks@ioe.uni-mysore.ac.in.
Jazyk: angličtina
Zdroj: Cancer metastasis reviews [Cancer Metastasis Rev] 2024 Mar; Vol. 43 (1), pp. 5-27. Date of Electronic Publication: 2023 Aug 08.
DOI: 10.1007/s10555-023-10129-8
Abstrakt: The hypoxic environment is prominently witnessed in most solid tumors and is associated with the promotion of cell proliferation, epithelial-mesenchymal transition (EMT), angiogenesis, metabolic reprogramming, therapeutic resistance, and metastasis of tumor cells. All the effects are mediated by the expression of a transcription factor hypoxia-inducible factor-1α (HIF-1α). HIF-1α transcriptionally modulates the expression of genes responsible for all the aforementioned functions. The stability of HIF-1α is regulated by many proteins and non-coding RNAs (ncRNAs). In this article, we have critically discussed the crucial role of ncRNAs [such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), Piwi-interacting RNAs (piRNAs), and transfer RNA (tRNA)-derived small RNAs (tsRNAs)] in the regulation of stability and expression of HIF-1α. We have comprehensively discussed the molecular mechanisms and relationship of HIF-1α with each type of ncRNA in either promotion or repression of human cancers and therapeutic resistance. We have also elaborated on ncRNAs that are in clinical examination for the treatment of cancers. Overall, the majority of aspects concerning the relationship between HIF-1α and ncRNAs have been discussed in this article.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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