The effects of cannabidiol on worry and anxiety among high trait worriers: a double-blind, randomized placebo controlled trial.

Autor: Gournay LR; University of Arkansas, 216 Memorial Hall, Fayetteville, AR, 72701, USA. lrgourna@uark.edu., Ferretti ML; University of Arkansas, 216 Memorial Hall, Fayetteville, AR, 72701, USA., Bilsky S; University of Mississippi, Oxford, USA., Vance E; University of Arkansas, 216 Memorial Hall, Fayetteville, AR, 72701, USA., Nguyen AM; University of Arkansas, 216 Memorial Hall, Fayetteville, AR, 72701, USA., Mann E; University of Arkansas, 216 Memorial Hall, Fayetteville, AR, 72701, USA.; Laureate Institute for Brain Research, Tulsa, USA., Williams P; University of Arkansas, 216 Memorial Hall, Fayetteville, AR, 72701, USA., Leen-Feldner EW; University of Arkansas, 216 Memorial Hall, Fayetteville, AR, 72701, USA.
Jazyk: angličtina
Zdroj: Psychopharmacology [Psychopharmacology (Berl)] 2023 Oct; Vol. 240 (10), pp. 2147-2161. Date of Electronic Publication: 2023 Aug 08.
DOI: 10.1007/s00213-023-06437-0
Abstrakt: Rationale: Evidence suggests cannabidiol (CBD) displays broad therapeutic potential in the context of anxiety; however, no study has examined the effects of CBD on worry, a defining, cognitive feature of anxiety. Additionally, no study has examined the effects of an acute, single dose of CBD compared to repeated CBD administration.
Objectives: Within a sample of 63 individuals with elevated trait worry, the current study aimed to assess the effects of an empirically-derived high dose of CBD (i.e., 300mg) compared to a commercially-derived dose of CBD (i.e., 50mg) versus placebo on worry severity and anxiety symptoms after an acute dose and after a 2-week administration period.
Results: Results indicated no effect of acute CBD dosing on worry severity or anxiety symptoms. Repeated CBD administration similarly did not impact worry severity; however, 300mg of CBD reduced anxiety symptoms across the 2-week administration period compared to placebo.
Conclusions: Taken together, these findings suggest 300mg of oral CBD does not attenuate cognitive symptoms of anxiety (i.e., worry), following both acute and repeated administration. Some evidence for repeated administration of 300mg on physical symptoms of anxiety was obtained. Findings from the current study suggest CBD's modest anxiolytic effects may be specific to the physical aspects of anxious arousal.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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