Complement.
| Autor: | Monach PA; VA Boston Healthcare System and Harvard Medical School, Boston, Massachusetts. |
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| Jazyk: | angličtina |
| Zdroj: | Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2024 Jan; Vol. 76 (1), pp. 1-8. Date of Electronic Publication: 2023 Oct 16. |
| DOI: | 10.1002/art.42671 |
| Abstrakt: | The role of complement in human autoimmune, inflammatory, and infectious diseases is reviewed, focusing on clinical applicability. A typical case is presented in which serum testing for C3 and C4 is performed to help assess a syndrome with a broad differential diagnosis. The review includes a discussion of complement deficiency states, consumption of complement by diseases characterized by immune-complex formation and deposition, usefulness and interpretation of laboratory tests for complement, and development of drugs targeting specific components of the complement pathway for a growing number of indications. (© 2023 American College of Rheumatology. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.) |
| Databáze: | MEDLINE |
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